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首页> 外文期刊>Biomaterials Science >Supramolecular nanomedicine derived from cucurbit[7]uril-conjugated nano-graphene oxide for multi-modality cancer therapy
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Supramolecular nanomedicine derived from cucurbit[7]uril-conjugated nano-graphene oxide for multi-modality cancer therapy

机译：衍生自葫芦纳米胺的超分子纳米胺用于多种癌症治疗的尿道[7]尿蛋白缀合的纳米石墨烯氧化物

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摘要

Nano-graphene oxide (NGO) has attracted increasing attention as an advanced drug delivery system. However, the current surface functionalization and drug-loading of NGO either rely on pi-pi stacking that is limited to aromatic molecules, or covalent conjugation that requires tedious synthesis. Herein, we developed the first cucurbit[7]uril (CB[7])-conjugated NGO (NGO-CB[7]) that allows non-covalent, modular surface functionalization and drug loading via not only traditional pi-pi stacking interactions between the NGO surface and functional molecules, but also strong host-guest interactions between CB[7] and guest payloads or adamantane (ADA)-tagged functional molecules, for more versatile biomedical applications. To this end, chlorin e6 (Ce6, a photosensitizer), banoxantrone dihydrochloride (AQ4N, a hypoxia-responsive prodrug) and oxaliplatin (OX, a guest of CB[7]) were co-loaded onto NGO-CB[7] via pi-pi stacking and host-guest interactions, respectively. Subsequently, ADA-tagged hyaluronic acid (ADA-HA) wrapped NGO-CB[7] non-covalently via CB[7]-ADA host-guest interactions to improve the physiological stability and overall biocompatibility of this supramolecular nanosystem, and to enable targeted delivery into cancer cells with CD44 receptors overexpressed. Remarkably, this supramolecular nanomedicine exhibited significant antitumor efficacy via combined photothermal/photodynamic therapy (PTT/PDT) from NGO/Ce6, as well as dual chemotherapy from OX and AQ4N (activated by PDT-enhanced hypoxia), in vitro and in vivo. This study not only offers a new supramolecular inorganic/organic hybrid nanosystem for multi-modality cancer therapy, but may also provide important new insights into noncovalent functionalization of other carbon nanomaterials and inorganic nanomaterials leading to multifunctional drug delivery systems.
机译：纳米石墨烯氧化物（NGO）吸引了越来越多的药物输送系统。然而，NGO的目前表面官能化和药物负载依赖于PI-PI堆叠，其限于芳族分子，或需要繁琐合成的共价缀合。在此，我们开发了第一个葫芦[7] URIL（CB [7]） - 缀合的NGO（NGO-CB [7]），其允许通过不仅通过之间的传统PI-PI堆叠相互作用而非共价，模块化表面官能化和药物负载NGO表面和功能分子，也是CB [7]和客人有效载荷或亚烷烷（ADA） - 代格功能分子之间强的宿主客房相互作用，用于更通用的生物医学应用。为此，通过PI将氯丙酮二盐酸盐（Ce6，光敏剂），香菜蒽酮二盐（AQ4N，缺氧前药物（AQ4N，CB [7]的嘉宾，ob，A的宾客，of CB [7]）加载到NGO-CB [7]上-PI堆叠和主机 - 访客交互。随后，ADA标记的透明质酸（ADA-HA）包裹着NGO-CB [7]非共价通过CB [7] --ADA宿主 - 客体相互作用，提高该超分子纳米系统的生理稳定性和整体生物相容性，并实现靶向用过表达的CD44受体递送进癌细胞。值得注意的是，这种超分子纳米胺通过非政府组织/ CE6的组合光热/光动力疗法（PTT / PDT）以及来自OX和AQ4N（受PDT-增强的缺氧激活）的双化疗，体外和体内激活的显着抗肿瘤疗效。本研究不仅为多种式癌症治疗提供了一种新的超分子无机/有机杂交纳米系统，而且还可以为其他碳纳米材料和无机纳米材料的非共价官能化提供重要的新见解，导致多功能药物递送系统。

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  • 来源
    《Biomaterials Science》 |2021年第10期|共10页
  • 作者

    Ding Yuan-Fu; Kwong Cheryl H. T.; Li Shengke; Pan Ya-Ting; Wei Jianwen; Wang Lian-Hui; Mok Greta S. P.; Wang Ruibing;

  • 作者单位

    Univ Macau Biomed Imaging Lab BIG Dept Elect &

    Comp Engn Taipa Macao Peoples R China;

    Univ Macau Inst Chinese Med Sci State Key Lab Qual Res Chinese Med Taipa Macao Peoples R China;

    Univ Macau Inst Chinese Med Sci State Key Lab Qual Res Chinese Med Taipa Macao Peoples R China;

    Univ Macau Inst Chinese Med Sci State Key Lab Qual Res Chinese Med Taipa Macao Peoples R China;

    Univ Macau Inst Chinese Med Sci State Key Lab Qual Res Chinese Med Taipa Macao Peoples R China;

    Nanjing Univ Posts &

    Telecommun Inst Adv Mat IAM Jiangsu Key Lab Riosensors 9 Wenyuan Rd Nanjing 210023 Peoples R China;

    Univ Macau Biomed Imaging Lab BIG Dept Elect &

    Comp Engn Taipa Macao Peoples R China;

    Univ Macau Inst Chinese Med Sci State Key Lab Qual Res Chinese Med Taipa Macao Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 分子生物学;
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