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首页> 外文期刊>Biomaterials Science >PEG-poly(amino acid)s/EpCAM aptamer multifunctional nanoparticles arrest the growth and metastasis of colorectal cancer
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PEG-poly(amino acid)s/EpCAM aptamer multifunctional nanoparticles arrest the growth and metastasis of colorectal cancer

机译：PEG聚（氨基酸）S / EPCAM适体多功能纳米粒子抑制了结直肠癌的生长和转移

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摘要

Tanshinone II-A (TSIIA) is a derivative of a phenanthrene-quinone extracted from a TCM herb, Salvia miltiorrhiza, and has been widely adopted in the treatment of colorectal cancer (CRC). It is known that TSIIA can lead to the apoptosis and differentiation of certain cell lines and it suppresses the proliferation and metastasis of tumors. However, its poor water solubility and low bioavailability when taken orally have prevented this drug being utilized effectively in the body. A nanoparticle (NP) drug carrier system is a technology that can effectively improve drug utilization and targeting ability. In this study, a new NP drug carrier system is reported: EpCAM targeting TSIIA-encapsulated poly(amino acid)s NPs (EpCAM-TSIIA-NPs). The results show that this new targeted NP drug carrier system has higher cytotoxicity, better water solubility and better targeting ability, and can effectively suppress the proliferation and metastasis of tumors. In addition, the invasion and metastasis mechanism of colorectal cancer (CRC) under beta-catenin nuclear meditation suppressed by EpCAM-TSIIA-NPs is also discussed. It is found that the immune-targeted type EpCAM-TSIIA-NPs could effectively enhance the expression of APC and axin when compared to normal NPs. It could improve the stability of beta-catenin destruction complex and suppress the occurrence and progression of tumors by stopping the nuclear activities of beta-catenin.
机译：丹参酮II-A（TSIIA）是一种从中医草本，丹参米尔蒂氏菌提取的菲尼醌的衍生物，并且已被广泛采用结直肠癌（CRC）。众所周知，Tsiia可以导致某些细胞系的凋亡和分化，抑制肿瘤的增殖和转移。然而，它在口服时，其水溶解度差和低生物利用度可防止在体内有效使用这种药物。纳米粒子（NP）药物载体系统是一种能够有效提高药物利用和靶向能力的技术。在本研究中，据报道了一种新的NP药物载体系统：EPCAM靶向TSIIA - 包封的聚（氨基酸）的NPS（EPCAM-TSIIA-NPS）。结果表明，这种新的靶向NP药物载体系统具有较高的细胞毒性，更好的水溶性和更好的靶向能力，可以有效地抑制肿瘤的增殖和转移。此外，还讨论了EPCAM-TSIIA-NPS抑制了β-连环蛋白核冥想下的结直肠癌（CRC）的侵袭和转移机制。结果发现，与正常NPS相比，免疫靶向型EPCAM-TSIIA-NPS可以有效地增强APC和轴的表达。它可以通过阻止β-catenin的核活动来改善β-连环蛋白破坏复合物的稳定性，抑制肿瘤的发生和进展。

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  • 来源
    《Biomaterials Science》 |2021年第10期|共13页
  • 作者

    Zhang Yingru; Li Chunpu; Jia Ru; Gao Ruixuan; Zhao Yiyang; Ji Qing; Cai Jianfeng; Li Qi; Wang Yan;

  • 作者单位

    Shanghai Univ Tradit Chinese Med Shuguang Hosp Dept Med Oncol Shanghai 201203 Peoples R China;

    Shanghai Univ Tradit Chinese Med Shuguang Hosp Dept Med Oncol Shanghai 201203 Peoples R China;

    Shanghai Univ Tradit Chinese Med Shuguang Hosp Dept Med Oncol Shanghai 201203 Peoples R China;

    Univ S Florida Dept Chem 4202 E Fowler Ave Tampa FL 33620 USA;

    Shanghai Univ Tradit Chinese Med Shuguang Hosp Dept Med Oncol Shanghai 201203 Peoples R China;

    Shanghai Univ Tradit Chinese Med Shuguang Hosp Dept Med Oncol Shanghai 201203 Peoples R China;

    Univ S Florida Dept Chem 4202 E Fowler Ave Tampa FL 33620 USA;

    Shanghai Univ Tradit Chinese Med Shuguang Hosp Dept Med Oncol Shanghai 201203 Peoples R China;

    Shanghai Univ Tradit Chinese Med Shuguang Hosp Dept Med Oncol Shanghai 201203 Peoples R China;

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  • 正文语种 eng
  • 中图分类 分子生物学;
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