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Biological sealing and integration of a fibrinogen-modified titanium alloy with soft and hard tissues in a rat model

机译：大鼠模型中纤维蛋白原改性钛合金与纤维蛋白原改性钛合金的生物密封和整合

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摘要

Percutaneous or transcutaneous devices are important and unique, and the corresponding biological sealing at the skin-implant interface is the key to their long-term success. Herein, we investigated the surface modification to enhance biological sealing, using a metal sheet and screw bonded by biomacromolecule fibrinogen mediated via pre-deposited synthetic macromolecule polydopamine (PDA) as a demonstration. We examined the effects of a Ti-6Al-4V titanium alloy modified with fibrinogen (Ti-Fg), PDA (Ti-PDA) or their combination (Ti-PDA-Fg) on the biological sealing and integration with skin and bone tissues. Human epidermal keratinocytes (HaCaT), human foreskin fibroblasts (HFF) and preosteoblasts (MC3T3-E1), which are closely related to percutaneous implants, exhibited better adhesion and spreading on all the three modified sheets compared with the unmodified alloy. After three-week subcutaneous implantation in Sprague-Dawley (SD) rats, the Ti-PDA-Fg sheets could significantly attenuate the soft tissue response and promote angiogenesis compared with other groups. Furthermore, in the model of percutaneous tibial implantation in SD rats, the Ti-PDA-Fg screws dramatically inhibited epithelial downgrowth and promoted new bone formation. Hence, the covalent immobilization of fibrinogen through the precoating of PDA is promising for enhanced biological sealing and osseointegration of metal implants with soft and hard tissues, which is critical for an orthopedic percutaneous medical device.
机译：经皮或经皮装置是重要的，独特的，并且皮肤植入界面的相应生物密封是他们长期成功的关键。在此，我们研究了使用金属片和通过通过预沉积的合成大分子多德莫（PDA）介导的生物致粒细胞纤维蛋白原的螺杆作为示范来增强生物密封的表面改性。我们检查了Ti-6Al-4V钛合金改性用纤维蛋白原（Ti-FG），PDA（Ti-PDA）或其组合（Ti-PDA-FG）的效果对生物密封和与皮肤和骨组织的整合。与未修饰的合金相比，人体表皮角细胞（HACAT），人包皮成纤维细胞（HACAT），人包皮成纤维细胞（HAC3T）和预卵形细胞（MC3T3-E1）与经皮植入物密切相关，在所有三个改性片材上表现出更好的粘附和扩散。在Sprague-Dawley（SD）大鼠中三周的皮下植入后，与其他组相比，Ti-PDA-FG片材可以显着衰减软组织响应并促进血管生成。此外，在SD大鼠的经皮胫骨植入模型中，Ti-PDA-FG螺钉显着抑制上皮间流动和促进新的骨形成。因此，通过PDA的刻度来通过纤维蛋白原的共价固定是有利于增强具有软和硬组织的金属植入物的生物密封和骨整合，这对于整形外科医疗装置至关重要。

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  • 来源
    《Biomaterials Science》 |2021年第15期|共17页
  • 作者

    Wang Xiuli; Lei Xing; Yu Yue; Miao Sheng; Tang Jingyu; Fu Ye; Ye Kai; Shen Yang; Shi Jiayue; Wu Hao; Zhu Yi; Yu Lin; Pei Guoxian; Bi Long; Ding Jiandong;

  • 作者单位

    Fudan Univ Dept Macromol Sci State Key Lab Mol Engn Polymers Shanghai 200438 Peoples R China;

    Fourth Mil Med Univ Xijing Hosp Dept Orthoped Xian 710032 Peoples R China;

    Fudan Univ Dept Macromol Sci State Key Lab Mol Engn Polymers Shanghai 200438 Peoples R China;

    Fourth Mil Med Univ Xijing Hosp Dept Orthoped Xian 710032 Peoples R China;

    Fudan Univ Dept Macromol Sci State Key Lab Mol Engn Polymers Shanghai 200438 Peoples R China;

    Fudan Univ Dept Macromol Sci State Key Lab Mol Engn Polymers Shanghai 200438 Peoples R China;

    Fudan Univ Dept Macromol Sci State Key Lab Mol Engn Polymers Shanghai 200438 Peoples R China;

    Fudan Univ Dept Macromol Sci State Key Lab Mol Engn Polymers Shanghai 200438 Peoples R China;

    Fudan Univ Dept Macromol Sci State Key Lab Mol Engn Polymers Shanghai 200438 Peoples R China;

    Fourth Mil Med Univ Xijing Hosp Dept Orthoped Xian 710032 Peoples R China;

    Fudan Univ Dept Macromol Sci State Key Lab Mol Engn Polymers Shanghai 200438 Peoples R China;

    Fudan Univ Dept Macromol Sci State Key Lab Mol Engn Polymers Shanghai 200438 Peoples R China;

    Fourth Mil Med Univ Xijing Hosp Dept Orthoped Xian 710032 Peoples R China;

    Fourth Mil Med Univ Xijing Hosp Dept Orthoped Xian 710032 Peoples R China;

    Fudan Univ Dept Macromol Sci State Key Lab Mol Engn Polymers Shanghai 200438 Peoples R China;

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  • 正文语种 eng
  • 中图分类 分子生物学;
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