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首页> 外文期刊>Biomaterials Science >3D printed gelatin/hydroxyapatite scaffolds for stem cell chondrogenic differentiation and articular cartilage repair
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3D printed gelatin/hydroxyapatite scaffolds for stem cell chondrogenic differentiation and articular cartilage repair

机译：用于干细胞软骨内分化和关节软骨修复的3D印刷明胶/羟基磷灰石支架

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摘要

Acute injury of the articular cartilage can lead to chronic disabling conditions because of the limited self-repair capability of the cartilage. Implantation of stem cells at the injury site is a viable treatment, but requires a scaffold with a precisely controlled geometry and porosity in the 3D space, high biocompatibility, and the capability of promoting chondrogenic differentiation of the implanted stem cells. Here we report the development of gelatin/hydroxyapatite (HAP) hybrid materials by microextrusion 3D bioprinting and enzymatic cross-linking as the scaffold for human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs). The scaffold supports the adhesion, growth, and proliferation of hUCB-MSCs and induces their chondrogenic differentiation in vitro. Doping HAP in the gelatin scaffold increases the fluidity of the hydrogel, improves the gelation kinetics and the rheological properties, and allows better control over 3D printing. Implanting the hUCB-MSC-laden scaffold at the injury site of the articular cartilage effectively repairs the cartilage defects in a pig model. Altogether, this work demonstrates the 3D printing of gelatin-based scaffold materials for hUCB-MSCs to repair cartilage defects as a potential treatment of articular cartilage injury.
机译：由于软骨的自修复能力有限，关节软骨的急性损伤可导致慢性致残条件。在损伤部位植入干细胞是一种可行的处理，但需要具有精确控制的几何形状和3D空间的孔隙率的支架，高生物相容性以及促进植入干细胞的软骨形成分化的能力。在这里，我们通过微扒窃3D生物制品的明胶/羟基磷灰石（HAP）杂种材料的开发和酶联交联作为人脐带血液源性间充质干细胞（HUCB-MSCs）的支架。支架支持HUCB-MSCs的粘附，生长和增殖，并在体外诱导其软骨内分化。在明胶支架中掺杂Hap增加了水凝胶的流动性，改善了凝胶化动力学和流变性能，并更好地控制3D印刷。植入关节软骨损伤部位的HUCB-MSC-LADEN支架有效地修复了猪模型中的软骨缺陷。完全，这项工作证明了用于Hucb-MSC的基于明胶的支架材料的3D印刷，以修复软骨缺陷作为关节软骨损伤的潜在处理。

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  • 来源
    《Biomaterials Science》 |2021年第7期|共11页
  • 作者

    Huang Jianghong; Huang Zhiwang; Liang Yujie; Yuan Weihao; Bian Liming; Duan Li; Rong Zhibin; Xiong Jianyi; Wang Daping; Xia Jiang;

  • 作者单位

    Shenzhen Univ Dept Orthoped Hlth Sci Ctr Shenzhen Peoples Hosp Guangdong Artificial Intelligence Biomed Innovat Shenzhen Intelligent Orthopaed &

    Biomed Innovat P Shenzhen 518035 Peoples R China;

    Shenzhen Univ Dept Orthoped Hlth Sci Ctr Shenzhen Peoples Hosp Guangdong Artificial Intelligence Biomed Innovat Shenzhen Intelligent Orthopaed &

    Biomed Innovat P Shenzhen 518035 Peoples R China;

    Chinese Univ Hong Kong Sch Life Sci Dept Chem Shatin Hong Kong Peoples R China;

    Chinese Univ Hong Kong Dept Biomed Engn Shatin Hong Kong Peoples R China;

    Chinese Univ Hong Kong Dept Biomed Engn Shatin Hong Kong Peoples R China;

    Shenzhen Univ Dept Orthoped Hlth Sci Ctr Shenzhen Peoples Hosp Guangdong Artificial Intelligence Biomed Innovat Shenzhen Intelligent Orthopaed &

    Biomed Innovat P Shenzhen 518035 Peoples R China;

    Shijiazhuang Matern &

    Child Hlth Hosp Shijiazhuang 050093 Hebei Peoples R China;

    Shenzhen Univ Dept Orthoped Hlth Sci Ctr Shenzhen Peoples Hosp Guangdong Artificial Intelligence Biomed Innovat Shenzhen Intelligent Orthopaed &

    Biomed Innovat P Shenzhen 518035 Peoples R China;

    Shenzhen Univ Dept Orthoped Hlth Sci Ctr Shenzhen Peoples Hosp Guangdong Artificial Intelligence Biomed Innovat Shenzhen Intelligent Orthopaed &

    Biomed Innovat P Shenzhen 518035 Peoples R China;

    Chinese Univ Hong Kong Sch Life Sci Dept Chem Shatin Hong Kong Peoples R China;

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  • 正文语种 eng
  • 中图分类 分子生物学;
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