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Carboxylic acid consumption and production by Corynebacterium glutamicum

机译：羧酸消耗和生产通过棒状杆菌谷氨酰胺

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Abstract > Corynebacterium glutamicum is well‐known as an industrial workhorse, most notably for its use in the bulk production of amino acids in the feed and food sector. Previous studies of the effect of gradients in scale‐down reactors with complex media disclosed an accumulation of several carboxylic acids and a parallel decrease of growth and product accumulation. This study, therefore, addresses the impact of carboxylic acids, for example, acetate and <sc>l</sc> ‐lactate, on the cultivation of the cadaverine producing strain C. glutamicum DM1945Δ act3:P <sub>tuf</sub> ‐ ldcC opt and their potential role in scale up related performance losses. A fluctuating power input in shake flask and stirred tank cultivations with mineral salt was applied to mimic discontinuous oxygen availability. > Results demonstrate, whenever sufficient oxygen was available, C. glutamicum recovered from previously occurring stressful conditions like an oxygen limiting phase. Reassimilation of acids was detected simultaneously. In cultures, which were supplemented with either acetate or <sc>l</sc> ‐lactate, a rapid cometabolization of both acids in presence of glucose was observed, showing conversion rates of 7.8 and 3.8 mmol g <sub>cell dry weight</sub> ?1 hr ?1 , respectively. Uptake of these acids was accompanied by increased oxygen consumption. Proteins related to oxidative stress response, glycogen synthesis, and the main carbon metabolism were found in altered concentrations under oscillatory cultivation conditions. (Proteomics data are available via ProteomeXchange with identifier PXD012760). Virtually no impact on growth or product formation was observed. We conclude that the reduced growth and product formation in scale‐down cultivations when complex media was used is not caused by the accumulation of carboxylic acids. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> > 棒状杆菌（Corynebacterium glutamicum）</ i> 是众所周知的工业主力，最值得注意的是，它在饲料和食品领域的氨基酸的散装生产中使用。以前研究梯度与复杂培养基的尺度下反应器的影响公开了几种羧酸的积累和生长和产物积累的平行降低。因此，该研究解决了羧酸的影响，例如醋酸盐和 <sc> l </ sc> - 寄生，关于野兔生产菌株的培养 c。谷氨酸</ i> DM1945Δ. ACT3：P. <sub> tuf </ sub> </ i> - LDCC. opt </ sup> </ i> 及其在扩大相关性能损失方面的潜在作用。摇动烧瓶中的波动功率输入和矿物盐的搅拌罐培养以模仿不连续的氧可用性。 </ p> > 结果表明，每当有足够的氧气时， c。谷氨酸</ i> 从以前发生的压力条件从以前发生的氧气限制阶段回收。同时检测酸的再溶剂。在培养物中，其补充有醋酸盐或 <sc> l </ sc> - 寄生，观察到葡萄糖存在下两种酸的快速cometabolization，显示转化率为7.8和3.8mmol g <sub>细胞干重</ sub> ？1 </ sup> 人力资源？1 </ sup> ，分别。吸收这些酸伴随着增加的氧气消耗量。在振荡培养条件下，发现与氧化应激反应，糖合成合成和主要碳代谢相关的蛋白质。（蛋白质组学数据通过Proteomexchange提供标识符PXD012760）。几乎没有观察到对生长或产品形成的影响。我们得出结论，当使用复杂培养基时，甲基酸的积累不会引起甲酸的积分培养中的增长和产物形成降低。 </ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-15005/'>《Biotechnology Progress》</a> <b style="margin: 0 2px;">|</b><span>2019年第3期</span><b style="margin: 0 2px;">|</b><span>共11页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Conrady Marius&option=202" target="_blank" rel="nofollow">Conrady Marius;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lemoine Anja&option=202" target="_blank" rel="nofollow">Lemoine Anja;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Limberg Michael H.&option=202" target="_blank" rel="nofollow">Limberg Michael H.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Oldiges Marco&option=202" target="_blank" rel="nofollow">Oldiges Marco;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Neubauer Peter&option=202" target="_blank" rel="nofollow">Neubauer Peter;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Junne Stefan&option=202" target="_blank" rel="nofollow">Junne Stefan;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Biotechnology Bioprocess EngineeringTechnische Universit?t BerlinBerlin Germany;</p> <p>Department of Biotechnology Bioprocess EngineeringTechnische Universit?t BerlinBerlin Germany;</p> <p>Research Centre JuelichIBG‐1—Institute of Bio‐ and Geosciences BiotechnologyJuelich Germany;</p> <p>Research Centre JuelichIBG‐1—Institute of Bio‐ and Geosciences BiotechnologyJuelich Germany;</p> <p>Department of Biotechnology Bioprocess EngineeringTechnische Universit?t BerlinBerlin Germany;</p> <p>Department of Biotechnology Bioprocess EngineeringTechnische Universit?t BerlinBerlin Germany;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/15.html" title="生物科学">生物科学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=carboxylic acid&option=203" rel="nofollow">carboxylic acid;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Corynebacterium glutamicum&option=203" rel="nofollow">Corynebacterium glutamicum;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=heterogeneity&option=203" rel="nofollow">heterogeneity;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=oxygen oscillation&option=203" rel="nofollow">oxygen oscillation;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=scale down&option=203" rel="nofollow">scale down;</a> </p> <div class="translation"> 机译：羧酸;棒状杆菌谷氨酸;异质性;氧振荡;缩小; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_transactions-tianjin-university_thesis/0201290663623.html">Engineering Corynebacterium glutamicum for Geraniol Production</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Man Li&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Man 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href="/academic-journal-foreign-pmc_detail_thesis/040003983217.html">Enhanced Glucose Consumption and Organic Acid Production by Engineered Corynebacterium glutamicum Based on Analysis of a pfkB1 Deletion Mutant</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Satoshi Hasegawa&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Satoshi Hasegawa,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yuya Tanaka&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Yuya Tanaka,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Masako Suda&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Masako Suda,</a> <span>2017</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：基于pfkB1缺失突变体的改造谷氨酸棒杆菌提高了葡萄糖的消耗和有机酸的产生。</span> </p> </li> <li> <div> <b>11. </b><a class="enjiyixqcontent" href="/open-access_resources_thesis/01000126757583.html">Production of Food and Feed Additives From Non-food-competing Feedstocks: Valorizing N-acetylmuramic Acid for Amino Acid and Carotenoid Fermentation With Corynebacterium glutamicum</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Elvira Sgobba&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Elvira Sgobba,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Luisa Blöbaum&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Luisa Blöbaum,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Volker F. Wendisch&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Volker F. Wendisch </a> <span>2018</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：从非食物竞争原料中生产食品和饲料添加剂：含有氨基酸和类胡萝卜素发酵的氨基酸和类氨基葡萄球菌的含量</span> </p> </li> <li> <div> <b>12. </b><a class="enjiyixqcontent" href="/ntis-science-report_ad_thesis/020712002239.html">Production of Azides of Carboxylic Acids and Acids of PhosphorusnPatent #154275</a> <b>[R] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=M. I. KABACHNIK&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">M. I. KABACHNIK,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=V. A. GILYAROV&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">V. A. GILYAROV </a> <span>1965</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：羧酸的叠氮化物和磷酸的酸的制备＃154275</span> </p> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_science-china-information-sciences_thesis/0201258360002.html">Metabolic engineering and flux analysis of Corynebacterium glutamicum for L-serine production</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=LAI ShuJuan&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . LAI ShuJuan</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=ZHANG Yun&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,ZHANG Yun</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=LIU ShuWen&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,LIU ShuWen</a> <span> <a href="/journal-cn-17558/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国科学 </a> </span> <span> . 2012</span><span>,第004期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-7894_thesis/020222020230.html">替换Corynebacterium glutamicum CYS菌染色体上的hisD启动子</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yongsong CHENG&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . Yongsong CHENG</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=程永松&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,程永松</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yunjiao ZHOU&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Yunjiao ZHOU</a> <span> <a href="/conference-cn-7894/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 2012氨基酸、有机酸产业发展论坛 </a> <span> <span> . 2012</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020313573202.html">Corynebacterium glutamicum血红素转运蛋白缺失对血红素代谢调控的影响</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=程雪莲&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 程雪莲</a> <span> . 2017</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/061203465534.html">一种利用重组Corynebacterium crenatum全细胞转化AD生成ADD的方法</a> <b>[P]</b> . <span> 中国专利： CN104531746B </span> <span> . 2019.09.03</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120103213092.html">一种利用重组Corynebacterium crenatum全细胞转化AD生成ADD的方法</a> <b>[P]</b> . <span> 中国专利： CN104531746A </span> <span> . 2015-04-22</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130402381573.html">RECOMBINANT CORYNEBACTERIUM GLUTAMICUM STRAIN FOR GLUTARIC ACID PRODUCTION AND GLUTARIC ACID PRODUCTION METHOD USING THE SAME</a> <b>[P]</b> . <span> 外国专利：  JP2020028292A </span> <span> . 2020-02-27</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：用于谷氨酸生产的重组谷氨酸棒杆菌菌株和使用相同方法生产谷氨酸的方法 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130500522451.html">CORYNEBACTERIUM GLUTAMICUM MUTANT STRAIN HAVING IMPROVED L-GLUTAMIC ACID PRODUCTION ABILITY, AND METHOD FOR PRODUCING L-GLUTAMIC ACID USING SAME</a> <b>[P]</b> . <span> 外国专利：  WO2021162189A1 </span> <span> . 2021-08-19</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：具有改善的L-谷氨酸生产能力的棒状杆菌突变体菌株，以及使用相同的L-谷氨酸的方法 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130444536111.html">Genes from corynebacterium glutamicum for the biosynthesis of folic acid and their use for the microbial production of folic acid.</a> <b>[P]</b> . <span> 外国专利：  ZA200200582B </span> <span> . 2003-03-26</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> 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