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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >The apoptotic effect of midazolam on the salivary gland of rats and the reversal effect by pilocarpine
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The apoptotic effect of midazolam on the salivary gland of rats and the reversal effect by pilocarpine

机译：咪达唑仑对大鼠唾液腺唾液腺的凋亡作用及皮豚鼠的逆转效应

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To evaluate the apoptosis in parotid glands of rats treated with midazolam associated or not with pilocarpine, 60 Wistar rats were assigned to 6 groups: control groups received saline solution for 30 days (S30) and 60 days (S60) and the other groups received pilocarpine for 60 days (P60), midazolam for 30 days (M30), midazolam for 30 days and 30 days of saline (M30 + S30), and finally midazolam for 30 days and 30 days of midazolam and pilocarpine (M30 + MP30). Histological sections were subjected to the TdT-mediated dUTP-biotin nick and labeling technique. The number of positive and negative cells was quantified, calculating the apoptotic index. ANOVA at 2 criteria and Tukey’s test were used. A greater apoptotic index was observed in the M30 (52.79 ± 9.01) and M30 + S30 (62.43 ± 8.52) groups when compared with the S30 (37.94 ± 5.94) and S60 (31.85 ± 9.18) groups, respectively (p < 0.05). There was no difference between M30 + MP30 (30.98 ± 6.19) and S60 (31.85 ± 9.18) groups regarding apoptotic index. Chronic administration of midazolam has been shown to increase the number of apoptotic cells in the parotid glands of rats. However, pilocarpine inhibited this effect, thus inhibiting the apoptosis.
机译：为了评估咪唑安定联合或不联合匹罗卡品治疗的大鼠腮腺中的细胞凋亡，60只Wistar大鼠被分为6组：对照组接受30天（S30）和60天（S60）的生理盐水，其他组接受60天（P60）、30天（M30）的咪唑安定、30天（M30+S30）的生理盐水，最后是30天的咪达唑仑，以及30天的咪达唑仑和匹罗卡品（M30+MP30）。组织切片采用TdT介导的dUTP生物素缺口标记技术。对阳性和阴性细胞的数量进行量化，计算凋亡指数。采用2个标准的方差分析和Tukey检验。与S30（37.94±5.94）和S60（31.85±9.18）组相比，M30（52.79±9.01）和M30+S30（62.43±8.52）组的凋亡指数更高（p<0.05）。M30+MP30（30.98±6.19）组和S60（31.85±9.18）组之间的凋亡指数没有差异。长期服用咪达唑仑可增加大鼠腮腺中凋亡细胞的数量。然而，毛果芸香碱抑制了这种作用，从而抑制了细胞凋亡。

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