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首页> 外文期刊>British journal of biomedical science >Serum long noncoding RNAs FAS-AS1 & PVT1 are novel biomarkers for systemic lupus erythematous
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Serum long noncoding RNAs FAS-AS1 & PVT1 are novel biomarkers for systemic lupus erythematous

机译：血清长度无量化RNAS-AS1和PVT1是新型生物标志物，用于全身狼疮红斑狼疮

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Background Systemic Lupus Erythematous (SLE) is a chronic systemic autoimmune disorder whose diagnosis depends on combination of multiple factors. Circulating lncRNAs could serve as diagnostic non-invasive biomarkers for SLE. We hypothesised that serum FAS-AS1 and PVT1 are new biomarkers for SLE that relate to clinical features and laboratory markers. Materials and Method Measurement of serum FAS-AS1 & PVT1 by qRT-PCR, analysis of the association between two RNAs and the clinical data, activity index and laboratory markers by standard routine methods. Results There was a significant relative increased serum FAS-AS1 (median (IQR) 2.19 (0.13-8.62) and a significant reduced PVT1 (median (IQR) 0.52 (0.01-7.55) in SLE patients compared to controls (P< 0.0001 for FAS-AS1 and = 0.007 for PVT1). Serum FAS-AS1 and PVT1 were positively correlated (r= 0.37,P= 0.001). Higher FAS-AS1 was significantly linked with nephritis (P= 0.011), positive anti-dsDNA (P= 0.01) and lower serum PVT1 was significantly associated with oral ulcers (P= 0.023), photosensitivity (P= 0.017), and neurological manifestations (P= 0.041). Serum PVT1 negatively correlated with age (r= -0.52,P< 0.0001) and ESR level (r= -0.29,P= 0.011) in SLE patients. No correlation between disease activity and serum FAS-AS1 or PVT1 was detected. Conclusions Our study provides evidence that serum FAS-AS1 and PVT1 are new biomarkers for SLE.
机译：背景系统性红斑狼疮（SLE）是一种慢性系统性自身免疫性疾病，其诊断依赖于多种因素的组合。循环lncRNAs可作为SLE的非侵入性诊断生物标志物。我们假设血清FAS-AS1和PVT1是SLE的新生物标志物，与临床特征和实验室标志物有关。材料和方法采用qRT-PCR检测血清FAS-AS1和PVT1，采用标准常规方法分析两种RNA与临床数据、活动指数和实验室标记物的相关性。结果与对照组相比，SLE患者的血清FAS-AS1（中位数（IQR）显著相对升高（2.19）（0.13-8.62），PVT1（中位数（IQR）显著降低（0.52）（0.01-7.55）（FAS-AS1组P<0.0001，PVT1组P=0.007）。血清FAS-AS1和PVT1呈正相关（r=0.37，P=0.001）。较高的FAS-AS1与肾炎（P=0.011）显著相关，抗双链DNA阳性（P=0.01）和较低的血清PVT1与口腔溃疡（P=0.023）、光敏性（P=0.017）和神经系统表现（P=0.041）显著相关。SLE患者血清PVT1与年龄（r=-0.52，P<0.0001）和ESR水平（r=-0.29，P=0.011）呈负相关。未检测到疾病活动与血清FAS-AS1或PVT1之间的相关性。结论我们的研究为血清FAS-AS1和PVT1是SLE的新生物标志物提供了证据。

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