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The Role of Interleukin-27 in Atherosclerosis: A Contemporary Review

机译：白细胞介素-27在动脉粥样硬化中的作用：当代评论

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摘要

Atherosclerosis is a chronic inflammation characterized by an imbalance between inhibitors and stimulators of the inflammatory system that leads to the formation of atherosclerotic plaques in the vessel walls. Interleukin (IL)-27 is one of the recently discovered cytokines that have an immunomodulatory role in autoimmune and inflammatory diseases. However, the definite role of IL-27 in the pathogenesis of atherosclerosis remains unclear. Recent studies on cardiomyocytes and vascular endothelium have demonstrated mechanisms through which IL-27 could potentially modulate atherosclerosis. Upregulation of the IL-27 receptor was also observed in the atherosclerotic plaques. In addition, circulatory IL-27 levels were increased in patients with acute coronary syndrome and myocardial infarction. A regenerative, neovascularization, and cardioprotective role of IL-27 has also been implicated. Future studies are warranted to elucidate the biologic function and clinical significance of IL-27 in atherosclerosis.
机译：动脉粥样硬化是一种慢性炎症，其特征是炎症系统的抑制剂和刺激剂之间的不平衡，导致血管壁形成动脉粥样硬化斑块。白细胞介素（IL）-27是最近发现的细胞因子之一，在自身免疫和炎症性疾病中具有免疫调节作用。然而，IL-27在动脉粥样硬化发病机制中的确切作用尚不清楚。最近对心肌细胞和血管内皮的研究表明，IL-27可能通过其机制调节动脉粥样硬化。在动脉粥样硬化斑块中也观察到IL-27受体上调。此外，急性冠脉综合征和心肌梗死患者的循环IL-27水平升高。IL-27也具有再生、新生血管和心脏保护作用。未来的研究需要阐明IL-27在动脉粥样硬化中的生物学功能和临床意义。

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