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首页> 外文期刊>Cardiology research and practice >Women Hospitalized for Acute on Chronic Decompensated Systolic Heart Failure Receive Less Furosemide Compared to Men
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Women Hospitalized for Acute on Chronic Decompensated Systolic Heart Failure Receive Less Furosemide Compared to Men

机译：与男性相比，患有慢性失代偿的收缩性心力衰竭的慢性失代偿结合的收缩性心力衰竭的妇女接受较少的呋塞米

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The cumulative incidence of systolic heart failure is similar in men and women. However, major prognostic differences exist between genders. We sought to measure gender differences in furosemide prescribing patterns for patients with preexisting heart failure with reduced ejection fraction (HFrEF) admitted with Stage C acute decompensation, regardless of the underlying cause. We conducted a single-center retrospective analysis of patients admitted between 2015 and 2018 for acute on chronic decompensated HFrEF. Primary outcomes were differences in initial furosemide dose, total dose over the first 24 hours of hospitalization, and total dose during the entire hospitalization between women and men. Secondary outcomes included acute kidney injury (AKI), intubation, noninvasive ventilation (NIV), and in-hospital 30-day and 1-year mortality. We studied 434 patients (31% female) with similar baseline characteristics. Females received significantly less furosemide compared to men for the initial dose, over the first 24 hours, and throughout their hospitalization. However, AKI was more prevalent in women versus men (p = 0.008). Females admitted for acute on chronic decompensated HFrEF receive significantly less furosemide when compared to men, but developed more AKI prior to discharge.
机译：男性和女性收缩性心力衰竭的累积发病率相似。然而，性别之间存在重大的预后差异。我们试图测量C期急性失代偿期患者既往存在射血分数降低的心力衰竭（HFrEF）患者的呋塞米处方模式的性别差异，而不考虑潜在原因。我们对2015年至2018年间因急性或慢性失代偿HFrEF入院的患者进行了单中心回顾性分析。主要结果是女性和男性在初始速尿剂量、住院前24小时的总剂量以及整个住院期间的总剂量方面的差异。次要转归包括急性肾损伤（AKI）、插管、无创通气（NIV）、住院30天和1年死亡率。我们研究了434名具有相似基线特征的患者（31%为女性）。在最初的24小时内，以及在整个住院期间，女性接受的速尿剂量明显低于男性。然而，与男性相比，AKI在女性中更为普遍（p=0.008）。与男性相比，因急性或慢性失代偿HFrEF入院的女性接受的速尿明显较少，但在出院前发生更多AKI。

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