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Sweet Sixteenth for ChREBP: Established Roles and Future Goals

机译:Chrebp的Sweet SixteNh:成立的角色和未来目标

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摘要

With the identification of ChREBP in 2001, our interest in understanding the molecular control of carbohydrate sensing has surged. While ChREBP was initially studied as a master regulator of lipogenesis in liver and fat tissue, it is now clear that ChREBP functions as a central metabolic coordinator in a variety of cell types in response to environmental and hormonal signals, with wide implications in health and disease. Celebrating its sweet sixteenth birthday, we review here the current knowledge about the function and regulation of ChREBP throughout usual and less explored tissues, to recapitulate ChREBP's role as a whole-body glucose sensor.
机译:随着2001年ChREBP的鉴定,我们对理解碳水化合物传感的分子控制的兴趣激增。虽然ChREBP最初是作为肝脏和脂肪组织中脂肪生成的主要调节因子进行研究的,但现在很清楚,ChREBP在各种细胞类型中作为中枢代谢协调器对环境和激素信号做出反应,在健康和疾病中具有广泛的意义。在庆祝它甜蜜的16岁生日之际,我们在这里回顾了目前关于ChREBP在正常和未被探索的组织中的功能和调节的知识,以概括ChREBP作为全身葡萄糖传感器的作用。

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