Quantitative Analysis of the Physiological Contributions of Glucose to the TCA Cycle

Liu Shiyu; Dai Ziwei; Cooper Daniel E.; Kirsch David G.; Locasale Jason W.

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Quantitative Analysis of the Physiological Contributions of Glucose to the TCA Cycle

机译：葡萄糖对TCA周期生理贡献的定量分析

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The nutritional source for catabolism in the tricarboxylic acid (TCA) cycle is a fundamental question in metabolic physiology. Limited by data and mathematical analysis, controversy exists. Using isotope-labeling data in vivo across several experimental conditions, we construct multiple models of central carbon metabolism and develop methods based on metabolic flux analysis (MFA) to solve for the preferences of glucose, lactate, and other nutrients used in the TCA cycle. We show that in nearly all circumstances, glucose contributes more than lactate as a substrate to the TCA cycle. This conclusion is verified in different animal strains from different studies and different administrations of C-13 glucose, and is extended to multiple tissue types. Thus, this quantitative analysis of organismal metabolism defines the relative contributions of nutrient fluxes in physiology, provides a resource for analysis of in vivo isotope tracing data, and concludes that glucose is the major nutrient used in mammals.

机译：三羧酸（TCA）循环分解代谢的营养来源是代谢生理学中的一个基本问题。受数据和数学分析的限制，存在争议。利用体内几个实验条件下的同位素标记数据，我们构建了多个中心碳代谢模型，并开发了基于代谢流量分析（MFA）的方法，以解决TCA循环中使用的葡萄糖、乳酸和其他营养素的偏好。我们发现，在几乎所有情况下，葡萄糖作为TCA循环的底物比乳酸贡献更多。这一结论在来自不同研究和不同C-13葡萄糖给药的不同动物品系中得到验证，并扩展到多种组织类型。因此，这种对生物代谢的定量分析定义了营养通量在生理学中的相对贡献，为体内同位素示踪数据的分析提供了资源，并得出结论，葡萄糖是哺乳动物使用的主要营养物质。

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《Cell metabolism》 |2020年第4期|共31页
作者
Liu Shiyu; Dai Ziwei; Cooper Daniel E.; Kirsch David G.; Locasale Jason W.;
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作者单位

Duke Univ Duke Ctr Genom &

Computat Biol Computat Biol &

Bioinformat Program Sch Med Durham NC;

Duke Univ Dept Pharmacol &

Canc Biol Sch Med Durham NC 27710 USA;

Duke Univ Dept Radiat Oncol Med Ctr Durham NC 27710 USA;

Duke Univ Dept Pharmacol &

Canc Biol Sch Med Durham NC 27710 USA;

Duke Univ Duke Ctr Genom &

Computat Biol Computat Biol &

Bioinformat Program Sch Med Durham NC;

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正文语种 eng
中图分类内分泌腺疾病及代谢病;
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机译：通过自动化贝叶斯分析NMR光谱的TCA周期周转和血清葡萄糖来源
7. Analysis of TCA cycle pathways and disposition of cycle intermediates in isolated rat heart mitochondria by carbon-13-NMR. [D] . Varadarajan, Deepta. 2000

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8. The quantitative relationship between isotopic and net contributions of lactate and glucose to the tricarboxylic acid (TCA) cycle [O] . Minfeng Ying, Cheng Guo, Xun Hu 2019

机译：乳酸和葡萄糖对三羧酸（TCA）循环的同位素和净贡献之间的定量关系
9. Quantitative Analysis of the Physiological Contributions of Glucose to the TCA Cycle [O] . Shiyu Liu, Ziwei Dai, Daniel E. Cooper, 2020

机译：葡萄糖对TCA周期的生理贡献的定量分析
10. Quantitative Analysis of Liquid Flow in Physiological Tubes [R] . Winet, H. 1982

机译：生理管内液体流动的定量分析

Quantitative Analysis of the Physiological Contributions of Glucose to the TCA Cycle

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