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The Gut Microbiota at the Service of Immunometabolism

机译:肠道微生物在免疫素描服务中

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摘要

The gut microbiota is implicated in immune system functions. Regulation of the metabolic processes occurring in immune cells is crucial for the maintenance of homeostasis and immunopathogenesis. Emerging data demonstrate that the gut microbiota is an actor in immunometabolism, notably through the effect of metabolites such as short-chain fatty acids, bile acids, and tryptophan metabolites. In this Perspective, we discuss the impact of the gut microbiota on the intracellular metabolism of the different subtypes of immune cells, including intestinal epithelial cells. Besides the effects on health, we discuss the potential consequences in infection context and inflammatory bowel diseases.
机译:肠道微生物群与免疫系统功能有关。免疫细胞代谢过程的调节对于维持体内平衡和免疫发病机制至关重要。新的数据表明,肠道微生物群在免疫代谢中起着重要作用,尤其是通过短链脂肪酸、胆汁酸和色氨酸代谢物等代谢物的作用。从这个角度出发,我们讨论了肠道微生物群对不同亚型免疫细胞(包括肠上皮细胞)的细胞内代谢的影响。除了对健康的影响,我们还讨论了感染和炎症性肠病的潜在后果。

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