Warmth Prevents Bone Loss Through the Gut Microbiota

Chevalier Claire; Kieser Silas; Colakoglu Melis; Hadadi Noushin; Brun Julia; Rigo Dorothee; Suarez-Zamorano Nicolas; Spiljar Martina; Fabbiano Salvatore; Busse Bjorn; Ivanisevic Julijana; Macpherson Andrew; Bonnet Nicolas; Trajkovski Mirko

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Warmth Prevents Bone Loss Through the Gut Microbiota

机译：温暖通过肠道微生物群防止骨质损失

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Osteoporosis is the most prevalent metabolic bone disease, characterized by low bone mass and microarchitectural deterioration. Here, we show that warmth exposure (34 degrees C) protects against ovariectomy-induced bone loss by increasing trabecular bone volume, connectivity density, and thickness, leading to improved biomechanical bone strength in adult female, as well as in young male mice. Transplantation of the warm-adapted microbiota phenocopies the warmth-induced bone effects. Both warmth and warm microbiota transplantation revert the ovariectomy-induced transcriptomics changes of the tibia and increase periosteal bone formation. Combinatorial metagenomics/metabolomics analysis shows that warmth enhances bacterial polyamine biosynthesis, resulting in higher total polyamine levels in vivo. Spermine and spermidine supplementation increases bone strength, while inhibiting polyamine biosynthesis in vivo limits the beneficial warmth effects on the bone. Our data suggest warmth exposure as a potential treatment option for osteoporosis while providing a mechanistic framework for its benefits in bone disease.

机译：骨质疏松症是最常见的代谢性骨病，其特点是骨量低和微结构退化。在这里，我们表明，温暖暴露（34摄氏度）通过增加小梁骨体积、连接密度和厚度来防止卵巢切除引起的骨丢失，从而提高成年雌性小鼠和年轻雄性小鼠的生物力学骨强度。热适应微生物群的移植可以复制热诱导的骨效应。温暖和温暖的微生物群移植都能逆转卵巢切除引起的胫骨转录组学变化，并增加骨膜骨形成。组合宏基因组学/代谢组学分析表明，温暖增强了细菌多胺的生物合成，导致体内总多胺水平更高。精胺和亚精胺的补充增加了骨强度，而抑制体内多胺生物合成限制了对骨的有益温暖效应。我们的数据表明，温暖暴露是骨质疏松症的一种潜在治疗选择，同时为其在骨骼疾病中的益处提供了一个机制框架。

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《Cell metabolism》 |2020年第4期|共23页
作者
Chevalier Claire; Kieser Silas; Colakoglu Melis; Hadadi Noushin; Brun Julia; Rigo Dorothee; Suarez-Zamorano Nicolas; Spiljar Martina; Fabbiano Salvatore; Busse Bjorn; Ivanisevic Julijana; Macpherson Andrew; Bonnet Nicolas; Trajkovski Mirko;
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Univ Geneva Ctr Med Univ CMU Fac Med Dept Cell Physiol &

Metab CH-1211 Geneva Switzerland;

Univ Geneva Ctr Med Univ CMU Fac Med Dept Cell Physiol &

Metab CH-1211 Geneva Switzerland;

Univ Geneva Ctr Med Univ CMU Fac Med Dept Cell Physiol &

Metab CH-1211 Geneva Switzerland;

Univ Geneva Ctr Med Univ CMU Fac Med Dept Cell Physiol &

Metab CH-1211 Geneva Switzerland;

Geneva Univ Hosp Div Bone Dis CH-1211 Geneva Switzerland;

Univ Geneva Ctr Med Univ CMU Fac Med Dept Cell Physiol &

Metab CH-1211 Geneva Switzerland;

Univ Geneva Ctr Med Univ CMU Fac Med Dept Cell Physiol &

Metab CH-1211 Geneva Switzerland;

Univ Geneva Ctr Med Univ CMU Fac Med Dept Cell Physiol &

Metab CH-1211 Geneva Switzerland;

Univ Geneva Ctr Med Univ CMU Fac Med Dept Cell Physiol &

Metab CH-1211 Geneva Switzerland;

Univ Clin Hamburg Inst Osteol &

Biomech D-22529 Hamburg Germany;

Univ Lausanne Fac Biol &

Med Metabol Unit CH-1005 Lausanne Switzerland;

Univ Bern Univ Clin Visceral Surg &

Med Bern Univ Hosp Inselspital Dept Biomed Res CH-3008 Bern;

Univ Geneva Fac Med Diabet Ctr CH-1211 Geneva Switzerland;

Univ Geneva Ctr Med Univ CMU Fac Med Dept Cell Physiol &

Metab CH-1211 Geneva Switzerland;

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正文语种 eng
中图分类内分泌腺疾病及代谢病;
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12. Prevent and Cure Disuse Bone Loss [R] . Jee, W. S. S. 1994

机译：预防和治疗废用骨质流失

Warmth Prevents Bone Loss Through the Gut Microbiota

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