...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell biology international. >Redox tolerance and metabolic reprogramming in solid tumors
【24h】

Redox tolerance and metabolic reprogramming in solid tumors

机译：实体肿瘤中的氧化还原耐受性和代谢重编程

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Tumor cells need to cope with the host environment for survival and keep growing in hard conditions. This suggests that tumors must acquire characteristics more potent than what is seen for normal tissue cells, without which they are condemned to disruption. For example, cancer cells have more potent redox tolerance compared with normal cells, which is due to their high adaptation to an oxidative crisis. In addition, increased demand for bioenergetics and biosynthesis can cause a rise in nutrient uptake in tumors. Utilizing nutrients in low nutrient conditions suggests that tumors are also equipped with adaptive metabolic processes. Switching the metabolic demands toward glucose consumption upon exposure to the hypoxic tumor microenvironment, or changing toward using other sources when there is an overconsumption of glucose in the tumor area are examples of fitness metabolic systems in tumors. In fact, cancer cells in cooperation with their nearby stroma (in a process called metabolic coupling) can reprogram their metabolic systems in their favor. This suggests the high importance of stroma for meeting the metabolic demands of a growing tumor, an example in this context is the metabolic symbiosis between cancer-associated fibroblasts with cancer cells. The point is that redox tolerance and metabolic reprogramming are interrelated, and that, without a doubt, disruption of redox tolerance systems by transient exposure to either oxidative or antioxidative loading, or targeting metabolic rewiring by modulation of tumor glucose availability, controlling tumor/stroma interactions, etc. can be effective from a therapeutic standpoint
机译：肿瘤细胞需要适应宿主环境才能生存，并在恶劣条件下继续生长。这表明肿瘤必须获得比正常组织细胞更强大的特征，没有这些特征，它们就注定要被破坏。例如，与正常细胞相比，癌细胞具有更强的氧化还原耐受性，这是由于它们对氧化危机的高度适应性。此外，对生物能学和生物合成的需求增加可能会导致肿瘤中营养吸收的增加。在低营养条件下利用营养物质表明肿瘤也具有适应性代谢过程。当暴露于缺氧的肿瘤微环境时，将代谢需求转变为葡萄糖消耗，或当肿瘤区域葡萄糖消耗过多时，改变为使用其他来源是肿瘤中适合代谢系统的例子。事实上，癌细胞与其附近的基质协同作用（在一个称为代谢偶联的过程中）可以对其代谢系统进行有利于它们的重新编程。这表明基质对于满足生长中肿瘤的代谢需求非常重要，肿瘤相关成纤维细胞与癌细胞之间的代谢共生就是一个例子。关键是氧化还原耐受和代谢重编程是相互关联的，毫无疑问，从治疗的角度来看，通过短暂暴露于氧化或抗氧化负荷，或通过调节肿瘤葡萄糖利用率、控制肿瘤/基质相互作用等靶向代谢重组来破坏氧化还原耐受系统，都是有效的

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号