Codelivery of survivin inhibitor and chemotherapeutics by tumor-derived microparticles to reverse multidrug resistance in osteosarcoma

Wei Daiqing; Li Cui; Ye Junwu; Xiang Feifan; Xu Yangbo; Liu Juncai

首页> 外文期刊>Cell biology international. >Codelivery of survivin inhibitor and chemotherapeutics by tumor-derived microparticles to reverse multidrug resistance in osteosarcoma

【24h】

Codelivery of survivin inhibitor and chemotherapeutics by tumor-derived microparticles to reverse multidrug resistance in osteosarcoma

机译：Survivin抑制剂和化学治疗剂的编码递送肿瘤衍生的微粒，在骨肉瘤中反转多药抗性

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Reportedly, the elevated expression of survivin has been observed in several tumor types, strictly involved in tumor development. In the present study, we detected elevated survivin expression in tumor tissues derived from patients with chemoresistant osteosarcoma when compared with those from chemosensitive patients. Importantly, knockdown of survivin in osteosarcoma cells significantly suppressed cell proliferation and chemoresistance both in vitro and in vivo. Simultaneously, chemotherapy mediates the upregulation of survivin in osteosarcoma cells through a survivin-based selective killing effect, resulting in the development of multidrug resistance. The utilization of tumor-derived microparticles to coencapsulate the survivin inhibitor YM155 and chemotherapeutic agents could effectively reverse multidrug resistance, leading to improved anticancer effects, as well as reduced systemic toxicity. In summary, the expression of survivin contributes to resistance toward osteosarcoma drugs, whereas employing survivin inhibiting combination therapy, based on a microparticle codelivery system, could efficiently reverse resistance and avoid potential systemic toxicity.

机译：据报道，在几种肿瘤类型中观察到了survivin的高表达，这些肿瘤与肿瘤的发展密切相关。在本研究中，我们检测到与化疗敏感患者相比，化疗耐药骨肉瘤患者肿瘤组织中survivin表达升高。重要的是，在体外和体内，骨肉瘤细胞中survivin的敲除显著抑制了细胞增殖和化疗耐药性。同时，化疗通过基于survivin的选择性杀伤效应介导骨肉瘤细胞中survivin的上调，导致多药耐药性的发展。利用肿瘤源性微粒联合包裹survivin抑制剂YM155和化疗药物可以有效逆转多药耐药性，从而提高抗癌效果，并降低全身毒性。总之，survivin的表达有助于对骨肉瘤药物产生耐药性，而基于微粒共递系统的survivin抑制联合治疗可以有效逆转耐药性并避免潜在的全身毒性。

著录项

来源
《Cell biology international.》 |2021年第2期|共12页
作者
Wei Daiqing; Li Cui; Ye Junwu; Xiang Feifan; Xu Yangbo; Liu Juncai;
展开▼
作者单位

Southwest Med Univ Affiliated Hosp Dept Orthopaed 25 Tai Ping St Luzhou 646000 Sichuan;

Southwest Med Univ Affiliated Hosp Dept Nosocomial Infect Control Luzhou Sichuan Peoples R;

Southwest Med Univ Affiliated Hosp Dept Orthopaed 25 Tai Ping St Luzhou 646000 Sichuan;

Southwest Med Univ Affiliated Hosp Dept Orthopaed 25 Tai Ping St Luzhou 646000 Sichuan;

Southwest Med Univ Affiliated Hosp Dept Orthopaed 25 Tai Ping St Luzhou 646000 Sichuan;

Southwest Med Univ Affiliated Hosp Dept Orthopaed 25 Tai Ping St Luzhou 646000 Sichuan;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词
chemoresistance; CIS; DOX; MPs; MTX; osteosarcoma; survivin; toxicity; YMamp; 8208; 115;

机译：化学钻石;CIS;dox;mps;mps;mtx;骨肉瘤;survivin;毒性;ym＆amp;8208;115;

相似文献

外文文献
中文文献
专利

1. Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles [J] . Jingwei Ma, Yi Zhang, Ke Tang, 细胞研究（英文版） . 2016,第006期
2. Sirolimus induces apoptosis and reverses multidrug resistance in human osteosarcoma cells in vitro via increasing microRNA-34b expression [J] . Yan ZHOU, Rui-hua ZHAO, Kuo-Fu TSENG, 中国药理学报：英文版 . 2016,第004期
3. Expression of Survivin Gene and Its Relationship with Clinical Multidrug Resistance in Osteosarcoma [J] . NIETao, DAIMin, ZONGShizhang 中德临床肿瘤学杂志：英文版 . 2005,第003期
4. Olmutinib (HM61713) reversed multidrug resistance by inhibiting the activity of ATPbinding cassette subfamily G member 2 in vitro and in vivo [J] . Zhiqiang Zhang, Liwu Fu, Xiaoran Guo, 药学学报（英文版） . 2018,第004期
5. Olmutinib(HM61713) reversed multidrug resistance by inhibiting the activity of ATPbinding cassette subfamily G member 2 in vitro and in vivo [J] . Zhiqiang Zhang, Xiaoran Guo, Kenneth K.W.To, 药学学报：英文版 . 2018,第004期
6. Codelivery of doxorubicin and JIP1 siRNA with novel EphA2-targeted PEGylated cationic nanoliposomes to overcome osteosarcoma multidrug resistance [J] . Fateme Haghiralsadat, Ghasem Amoabediny, Samira Naderinezhad, International Journal of Nanomedicine . 2018,第1期

机译：新型EphA2靶向的聚乙二醇化阳离子纳米脂质体与阿霉素和JIP1 siRNA的代码传递，以克服骨肉瘤多药耐药性
7. PDE5 inhibitors, sildenafil and vardenafil, reverse multidrug resistance by inhibiting the efflux function of multidrug resistance protein 7 (ATP‐binding Cassette C10) transporter [J] . Amit K. Tiwari, Dong-Hua Yang, Jun-Jiang Chen, Cancer science. . 2012,第8期

机译：PDE5抑制剂sildenafil和vardenafil可通过抑制多重耐药蛋白7（ATP结合盒式C10）转运蛋白的外排功能逆转多重耐药
8. PDE5 inhibitors, sildenafil and vardenafil, reverse multidrug resistance by inhibiting the efflux function of multidrug resistance protein 7 (ATP-binding Cassette C10) transporter [J] . ChenJ.-J., SunY.-L., TiwariA.K., Cancer science. . 2012,第8期

机译：PDE5抑制剂西地那非和伐地那非可通过抑制多药耐药蛋白7（ATP结合盒式C10）转运蛋白的外排功能逆转多药耐药性
9. Imaging Multidrug Resistance in Osteosarcoma: A Pre-clinical Approach Using an Orthotopic Animal Model [C] . CM. Gomes, M.M. Welling, l. Que, World congress on medical physics and biomedical engineering;International congress of the IUPESM . 2011

机译：成像在骨肉瘤中的多药耐药性：使用原位动物模型的临床前方法。
10. Telatinib reverses chemotherapeutic multidrug resistance by inhibiting ABCG2 efflux transporter in vitro and in vivo. [D] . Sodani, Kamlesh S. 2013

机译：替拉替尼通过在体外和体内抑制ABCG2外排转运蛋白来逆转化学疗法的多药耐药性。
11. NVP‐TAE684 reverses multidrug resistance (MDR) in human osteosarcoma by inhibiting P‐glycoprotein (PGP1) function [O] . Shunan Ye, *, Jianming Zhang, 2016

机译：NVP-TAE684通过抑制P-糖蛋白（PGP1）功能逆转人骨肉瘤中的多药耐药性（MDR）
12. NVP-TAE684 reverses multidrug resistance (MDR) in human osteosarcoma by inhibiting P-glycoprotein (PGP1) function [O] . Shunan Ye, Jianming Zhang, Jacson Shen, 2016

机译：通过抑制p-糖蛋白（PGP1）功能，NVP-TAE684反转人骨瘤中的多药耐药性（MDR）
13. Discovery of Potent Inhibitors for Breast Cancer Multidrug Resistance [R] . Chang, G. , Finn, M. G. , Urbatsch, I. 2006

机译：发现有效抑制剂对乳腺癌多药耐药性的影响

Codelivery of survivin inhibitor and chemotherapeutics by tumor-derived microparticles to reverse multidrug resistance in osteosarcoma

摘要

著录项

相似文献

相关主题

期刊订阅