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首页> 外文期刊>Cell biology international. >The multifaceted roles of nucleophagy in cancer development and therapy
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The multifaceted roles of nucleophagy in cancer development and therapy

机译：癌症发育与治疗中的多核苷酸的多方面作用

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摘要

Autophagy is an evolutionarily conserved process in which the cell degrades its own components and recycles the biomolecules for survival and homeostasis. It is an important cellular process to eliminate pathogens or damaged organelles. Nucleophagy, also termed as nuclear autophagy, is a more recently described subtype of autophagy, in which nuclear components, such as nuclear lamina and DNA, are to be degraded. Nucleophagy plays a double-facet role in the development of cancer. On one hand, the clearance of damaged DNA or nuclear structures via autophagic pathway is crucial to maintain nuclear integrity and prevent tumorigenesis. On the other hand, in later stages of tumor growth, nucleophagy may facilitate cancer cell survival and metastasis in the nutrient-depleted microenvironment. In this review, we discuss the relationship between nucleophagy and cancer along with potential intervention methods to target cancer through manipulating nucleophagy. Given the known observations about nucleophagy, it could be promising to target different nuclear components during the processes of nucleophagy, especially nuclear lamina. Further research on investigating the role of nucleophagy in oncological context could focus on dissecting its remaining molecular pathways and their connection to known tumor suppressors.
机译：自噬是一个进化上保守的过程，在这个过程中，细胞降解自己的成分，并回收生物分子以维持生存和内环境稳定。它是清除病原体或受损细胞器的重要细胞过程。核自噬，也被称为核自噬，是一种最近被描述的自噬亚型，其中核成分，如核层和DNA，将被降解。噬核在癌症的发展中起着双重作用。一方面，通过自噬途径清除受损的DNA或核结构对于维持核完整性和防止肿瘤发生至关重要。另一方面，在肿瘤生长的后期，噬核可能促进癌细胞在缺乏营养的微环境中存活和转移。在这篇综述中，我们讨论了噬核与癌症之间的关系，以及通过操纵噬核来靶向癌症的潜在干预方法。鉴于对噬核作用的已知观察，在噬核过程中靶向不同的核成分，尤其是核层可能是有希望的。进一步研究噬核在肿瘤学中的作用，可以集中于剖析其剩余的分子途径及其与已知肿瘤抑制因子的联系。

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