Neurotrophin signalling in amygdala-dependent cued fear learning

Meis Susanne; Endres Thomas; Lessmann Volkmar

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Neurotrophin signalling in amygdala-dependent cued fear learning

机译：神经营养蛋白信号在杏仁达拉依赖的恐惧学习中

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The amygdala is a central hub for fear learning assessed by Pavlovian fear conditioning. Indeed, the prevailing hypothesis that learning and memory are mediated by changes in synaptic strength was shown most convincingly at thalamic and cortical afferents to the lateral amygdala. The neurotrophin brain-derived neurotrophic factor (BDNF) is known to regulate synaptic plasticity and memory formation in many areas of the mammalian brain including the amygdala, where BDNF signalling via tropomyosin-related kinase B (TrkB) receptors is prominently involved in fear learning. This review updates the current understanding of BDNF/TrkB signalling in the amygdala related to fear learning and extinction. In addition, actions of proBDNF/p75NTR and NGF/TrkA as well as NT-3/TrkC signalling in the amygdala are introduced.

机译：杏仁核是巴甫洛夫恐惧条件反射评估的恐惧学习中枢。事实上，关于学习和记忆是由突触强度变化介导的普遍假设在丘脑和皮质传入外侧杏仁核时得到了最令人信服的证明。已知神经营养素脑源性神经营养因子（BDNF）可调节哺乳动物大脑许多区域的突触可塑性和记忆形成，包括杏仁核，其中BDNF通过原肌球蛋白相关激酶B（TrkB）受体发出信号，显著参与恐惧学习。这篇综述更新了目前对杏仁核内BDNF/TrkB信号与恐惧学习和消除相关的理解。此外，还介绍了proBDNF/p75NTR和NGF/TrkA以及NT-3/TrkC信号在杏仁核中的作用。

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《Cell and Tissue Research》 |2020年第1期|共12页
作者
Meis Susanne; Endres Thomas; Lessmann Volkmar;
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Otto von Guericke Univ Inst Physiol Med Fak Leipziger Str 44 D-39120 Magdeburg Germany;

Otto von Guericke Univ Inst Physiol Med Fak Leipziger Str 44 D-39120 Magdeburg Germany;

Otto von Guericke Univ Inst Physiol Med Fak Leipziger Str 44 D-39120 Magdeburg Germany;

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正文语种 eng
中图分类细胞生物学;
关键词
Amygdala; LTP; Fear; Extinction; BDNF; GABA;

机译：Amygdala;LTP;恐惧;灭绝;BDNF;GABA;

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9. Phasic signaling in the bed nucleus of the stria terminalis during fear learning predicts within- and across-session cued fear expression [O] . Max Bjorni, Natalie G. Rovero, Elissa R. Yang, 2020

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11. Fear-Potentiated Startle as a Model System for Analyzing Learning and Memory [R] . Davis, M. 1991

机译：作为分析学习和记忆的模型系统，恐惧势力惊吓

Neurotrophin signalling in amygdala-dependent cued fear learning

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