Peritoneal macrophages are impaired in cathelicidin-deficient mice systemically challenged with Escherichia coli

Boucher Emily; Brown Luke; Lahiri Priyoshi; Cobo Eduardo R.

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Peritoneal macrophages are impaired in cathelicidin-deficient mice systemically challenged with Escherichia coli

机译：腹膜巨噬细胞在水癌型蛋白缺乏的小鼠与大肠杆菌攻击的缺陷小鼠受损

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Cathelicidins are small, cationic peptides produced by macrophages with protective effects against infection although their involvement in phagocytosis is not fully understood. This study demonstrates that fewer macrophages were recruited in mice genetically deficient in cathelicidin (Camp(-/-)) during acute Escherichia coli-induced peritonitis and those macrophages had impaired phagocytosis. These defects seem due to endogenous functions of murine cathelicidin (CRAMP) as phagocytosis was not improved by synthetic human cathelicidin (LL-37) in a murine phagocytic cell line. This knowledge contributes to understanding the function of cathelicidins in the recruitment and function of phagocytic cells and differential roles between endogenous and exogenous cathelicidins.

机译：Cathelicidins是由巨噬细胞产生的小型阳离子肽，具有抗感染的保护作用，尽管它们参与吞噬作用尚不完全清楚。这项研究表明，在大肠杆菌诱导的急性腹膜炎期间，在遗传性缺乏cathelicidin（Camp（-/-）的小鼠中招募的巨噬细胞较少，并且这些巨噬细胞的吞噬功能受损。这些缺陷似乎是由于在小鼠吞噬细胞系中合成的人cathelicidin（LL-37）没有改善吞噬功能，因此小鼠cathelicidin（CRAP）的内源性功能所致。这些知识有助于理解cathelicidins在吞噬细胞募集和功能中的功能，以及内源性和外源性cathelicidins之间的差异作用。

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来源
《Cell and Tissue Research》 |2021年第3期|共6页
作者
Boucher Emily; Brown Luke; Lahiri Priyoshi; Cobo Eduardo R.;
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作者单位

Univ Calgary Cumming Sch Med Calgary AB Canada;

Univ Calgary Cumming Sch Med Microbiol Immunol &

Infect Dis Calgary AB Canada;

Univ Calgary Prod Anim Hlth Fac Vet Med Calgary AB Canada;

Univ Calgary Prod Anim Hlth Fac Vet Med Calgary AB Canada;

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原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词
Phagocytosis; Cathelicidin; Escherichia coli; Macrophage;

机译：吞噬作用;Cathelicidin;大肠杆菌;巨噬细胞;

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Peritoneal macrophages are impaired in cathelicidin-deficient mice systemically challenged with Escherichia coli

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