...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cellular immunology >Extracellular vesicles released by myeloid-derived suppressor cells from pregnant women modulate adaptive immune responses
【24h】

Extracellular vesicles released by myeloid-derived suppressor cells from pregnant women modulate adaptive immune responses

机译：来自孕妇的髓体衍生的抑制细胞释放的细胞外囊泡调节适应性免疫应答

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Immunological pregnancy complications are a main challenge in reproductive medicine. Mechanisms regulating the adaptation of the maternal immune system to pregnancy are incompletely understood and therapeutic options limited. Myeloid derived suppressor cells (MDSC) are immune-modulatory cells expanding during healthy pregnancy and seem to play a crucial role for maternal-fetal tolerance. Recent studies showed that exosomes produced by MDSC have immune-modulatory effects corresponding to their parental cells under different pathological conditions. Here, we investigated immunological effects of exosomes of GR-MDSC during pregnancy. Isolated GR-MDSC exosomes from peripheral blood of pregnant women were tested for functionality in different in vitro assays. We show that GR-MDSC exosomes exhibited profound immune-modulatory effects such as suppression of T-cell proliferation, T helper 2 (Th2)-cell polarization, induction of regulatory T-cells and inhibition of lymphocyte cytotoxicity. Our results confirm that MDSC-derived exosomes functionally correspond to their parental cells and identify them as an interesting therapeutic target for immunological pregnancy complications.
机译：免疫妊娠并发症是生殖医学面临的主要挑战。调节母体免疫系统对妊娠适应的机制尚不完全清楚，治疗选择也有限。髓源性抑制细胞（MDSC）是在健康妊娠期间扩张的免疫调节细胞，似乎对母婴耐受起着关键作用。最近的研究表明，在不同的病理条件下，MDSC产生的外显体具有与其亲代细胞相应的免疫调节作用。在这里，我们研究了怀孕期间GR-MDSC外显体的免疫效应。从孕妇外周血中分离的GR-MDSC外显体在不同的体外试验中进行功能测试。我们发现，GR-MDSC外显体具有深刻的免疫调节作用，如抑制T细胞增殖、T辅助细胞2（Th2）-细胞极化、诱导调节性T细胞和抑制淋巴细胞细胞毒性。我们的研究结果证实，MDSC衍生的外显体在功能上与其亲代细胞相对应，并将其确定为免疫妊娠并发症的有趣治疗靶点。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号