Tumor suppression by the histone demethylase UTX.

Tsai MC; Chang HY

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Tumor suppression by the histone demethylase UTX.

机译：由组蛋白脱甲基化酶UTX的肿瘤抑制。

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Aberrant regulation of chromatin can alter cell fates and result in unrestrained cell growth, leading to cancer development. Understanding the complex epigenetic pathways may point the way for advanced cancer therapy. Several recent studies identified mutations in components of the chromatin modification machinery in different types of cancer. Interestingly, these mutations include two important enzymes which are involved in histone H3 lysine 27 (H3K27) methylation, EZH2 (H3K27 methyltransferase) and UTX (H3K27 demethylase), consistent with the fact that abnormal H3K27me3 levels can cause tumorigensis.

机译：染色质的异常调节可以改变细胞命运，导致细胞生长不受限制，从而导致癌症的发展。了解复杂的表观遗传学途径可能为晚期癌症治疗指明方向。最近的几项研究在不同类型的癌症中发现了染色质修饰机制成分的突变。有趣的是，这些突变包括两种参与组蛋白H3赖氨酸27（H3K27）甲基化的重要酶，EZH2（H3K27甲基转移酶）和UTX（H3K27去甲基化酶），这与H3K27me3水平异常可导致肿瘤的事实相一致。

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《Cell cycle》 |2010年第11期|共2页
作者
Tsai MC; Chang HY;
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Howard Hughes Medical Institute and Program in Epithelial Biology Stanford University School of;

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正文语种 eng
中图分类细胞生物学;
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1. AOF1 is a histone H3K4 demethylase possessing demethylase activity-independent repression function [J] . Ze Yang, Jun Jiang, David M Stewart, 细胞研究：英文版 . 2010,第003期
2. AOF1 is a histone H3K4 demethylase possessing demethylase activity-independent repression function [J] . Ze Yang, Jun Jiang, David M Stewart, 细胞研究（英文版） . 2010,第003期
3. Coordinated regulation of active and repressive histone methylations by a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans [J] . Hanqing Lin, Yiqin Wang, Yanru Wang, 细胞研究：英文版 . 2010,第008期
4. Coordinated regulation of active and repressive histone methylations by a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans [J] . Hanqing Lin, Lulu Hu, Yan Lin, 细胞研究（英文版） . 2010,第008期
5. Development of the triazole-fused pyrimidine derivatives as highly potent and reversible inhibitors of histone lysine specific demethylase1(LSD1/KDM1A) [J] . Zhonghua Li134, Lina Ding134, Zhongrui Li134, 药学学报：英文版 . 2019,第004期
6. Tumor suppression by the histone demethylase UTX. [J] . Tsai MC, Chang HY Cell cycle . 2010,第11期

机译：组蛋白脱甲基酶UTX抑制肿瘤。
7. Tumor suppression by the histone demethylase UTX. [J] . Tsai MC, Chang HY Cell cycle . 2010,第11期

机译：组蛋白脱甲基酶UTX的肿瘤抑制。
8. Tumor suppression by the histone demethylase UTX. [J] . Tsai MC, Chang HY Cell cycle . 2010,第11期

机译：组蛋白脱甲基酶UTX的肿瘤抑制。
9. Ultra High-throughput MS Methods for the Discovery of Histone Demethylase Inhibitors [C] . John M. Peltier, Keeley Murphy, Nicole M. White, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：用于发现组蛋白去甲基酶抑制剂的超高通量MS方法
10. KDM4A and KDM4B histone demethylases: Tumor promoters and drug targets [D] . Berry, William L. 2013

机译：KDM4A和KDM4B组蛋白脱甲基酶：肿瘤启动子和药物靶标
11. Tumor suppression by the histone demethylase UTX [O] . Miao-Chih Tsai, Jordon K. Wang, Howard Y. Chang -1

机译：肿瘤抑制由组蛋白去甲基UTX
12. Tumor suppression by the histone demethylase UTX [O] . Miao-Chih Tsai, Jordon K. Wang, Howard Y. Chang 2010

机译：组蛋白脱甲基酶UTX的肿瘤抑制
13. Role of Histone Demethylase Jmjd3 in Immune Mediated Aplastic Anemia. [R] . Zhang, Y. 2017

机译：组蛋白去甲基化酶Jmjd3在免疫介导的再生障碍性贫血中的作用。

Tumor suppression by the histone demethylase UTX.

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