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首页> 外文期刊>Biological trace element research >A Cross-sectional Study of Plasma Trace Elements and Vitamins Content in Androgenetic Alopecia in Men
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A Cross-sectional Study of Plasma Trace Elements and Vitamins Content in Androgenetic Alopecia in Men

机译：血浆微量元素与男性血管生殖症状血浆含量的横截面研究

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Androgenetic alopecia (AGA) is the most common variant of male pattern baldness in which occurrence and development of multiple genetic, hormonal, and metabolic factors are involved. We aimed to estimate plasma element content (Mg, Ca, Zn, Cu, Se, Fe), vitamin status (B12, D, E, and folic acid) in patients with AGA using direct colorimetric tests or atomic absorption spectrometry, and the influence of these parameters in the formation of various hair loss patterns. The study included 50 patients with I-IV stages of AGA divided into two groups with normal and high levels of dihydro testosterone compared with 25 healthy individuals. The presence of two patterns of pathological hair loss in the androgen-dependent (parietal) and androgen-independent (occipital) areas of the scalp was confirmed. It was shown that all patients with AGA have a deficiency of elements (Zn, Cu, Mg, Se) and vitamins (B12, E, D, folic acid). However, the hair loss rate was not due to their content. А positive interrelation between quantitative trichogram parameters in the occipital region and iron metabolism in pairs "hair density vs Fe" and "hair diameter vs ferritin" was shown. In turn, in the parietal region, an inverse correlation of hair diameter with plasma Cu level was found, the most pronouncing in patients with high levels of dihydrotestosterone. The obtained results indicate the importance of multiple micronutrient deficiencies in the AGA occurrence accompanied by the existence of two different hair loss patterns, differently related to the content of certain trace elements and androgens in the blood.
机译：雄激素性秃发（AGA）是男性型秃发最常见的变体，其发生和发展涉及多种遗传、激素和代谢因素。我们旨在通过直接比色法或原子吸收光谱法评估AGA患者的血浆元素含量（镁、钙、锌、铜、硒、铁）、维生素状态（B12、D、E和叶酸），以及这些参数对各种脱发模式形成的影响。该研究包括50名AGA I-IV期患者，与25名健康人相比，分为两组，二氢睾酮水平正常和高。在雄激素依赖性（顶叶）和雄激素非依赖性（枕叶）头皮区域，存在两种病理性脱发模式。结果表明，所有AGA患者都缺乏元素（锌、铜、镁、硒）和维生素（B12、E、D、叶酸）。然而，脱发率并不是因为它们的含量。结果显示，枕区的定量毛图参数与成对铁代谢“头发密度与铁”和“头发直径与铁蛋白”之间存在正相关关系。反过来，在顶叶区域，发现头发直径与血浆铜水平呈负相关，在双氢睾酮水平高的患者中最明显。所得结果表明，多种微量营养素缺乏在AGA发生中的重要性，同时存在两种不同的脱发模式，与血液中某些微量元素和雄激素的含量有不同的关系。

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