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首页> 外文期刊>Cardiovascular engineering and technology >Large-Eddy Simulations of Flow in the FDA Benchmark Nozzle Geometry to Predict Hemolysis
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Large-Eddy Simulations of Flow in the FDA Benchmark Nozzle Geometry to Predict Hemolysis

机译：FDA基准喷嘴几何中流量的大涡流模拟预测溶血

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Purpose-Modeling of hemolysis due to fluid stresses faces significant methodological challenges, particularly in geometries with turbulence or complex flow patterns. It is currently unclear how existing phenomenological blood-damage models based on laminar viscous stresses can be implemented into turbulent computational fluid dynamics simulations. The aim of this work is to generalize the existing laminar models to turbulent flows based on first principles, and validate this generalization with existing experimental data. Methods-A novel analytical and numerical framework for the simulation of flow-induced hemolysis based on the intermittency-corrected turbulent viscous shear stress (ICTVSS) is introduced. The proposed large-eddy simulation framework is able to seamlessly transition from laminar to turbulent conditions in a single flow domain by linking laminar shear stresses to dissipation of mechanical energy, accounting for intermittency in turbulent dissipation, and relying on existing power-law hemolysis models. Simulations are run to reproduce previously published hemolysis data with bovine blood in a benchmark geometry. Two sets of experimental data are relied upon to tune power-law parameters and justify that tuning. The first presents hemolysis measurements in a simple laminar flow, and the second is hemolysis in turbulent flow through the FDA benchmark nozzle. Validation is performed by simulation of blood injected into a turbulent jet of phosphate-buffered saline, with modifications made to account for the local concentration of blood.
机译：目的：流体应力引起的溶血建模面临着重大的方法学挑战，尤其是在具有湍流或复杂流型的几何形状中。目前尚不清楚现有的基于层流粘性应力的唯象血液损伤模型如何应用于湍流计算流体力学模拟。本文的目的是基于第一性原理将现有的层流模型推广到湍流，并用现有的实验数据验证这种推广。方法：介绍了一种基于间歇校正湍流粘性剪切应力（ICTVSS）的流致溶血模拟新的分析和数值框架。通过将层流剪切应力与机械能耗散联系起来，考虑湍流耗散的间歇性，并依靠现有的幂律溶血模型，提出的大涡模拟框架能够在单个流场中无缝地从层流状态过渡到湍流状态。通过模拟，在基准几何结构中用牛血重现先前公布的溶血数据。根据两组实验数据来调整幂律参数，并证明这种调整是正确的。第一个是简单层流中的溶血测量，第二个是通过FDA基准喷嘴的湍流中的溶血测量。通过模拟注入磷酸盐缓冲盐水湍流射流的血液进行验证，并对局部血液浓度进行修改。

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