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首页> 外文期刊>Cerebral cortex >Development of the Neuro-Immune-Vascular Plexus in the Ventricular Zone of the Prenatal Rat Neocortex
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Development of the Neuro-Immune-Vascular Plexus in the Ventricular Zone of the Prenatal Rat Neocortex

机译：产前大鼠Neocortex的心室区神经免疫血管丛的发展

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Microglial cells make extensive contacts with neural precursor cells (NPCs) and affiliate with vasculature in the developing cerebral cortex. But how vasculature contributes to cortical histogenesis is not yet fully understood. To better understand functional roles of developing vasculature in the embryonic rat cerebral cortex, we investigated the temporal and spatial relationships between vessels, microglia, and NPCs in the ventricular zone. Our results show that endothelial cells in developing cortical vessels extend numerous fine processes that directly contact mitotic NPCs and microglia; that these processes protrude from vessel walls and are distinct from tip cell processes; and that microglia, NPCs, and vessels are highly interconnected near the ventricle. These findings demonstrate the complex environment in which NPCs are embedded in cortical proliferative zones and suggest that developing vasculature represents a source of signaling with the potential to broadly influence cortical development. In summary, cortical histogenesis arises from the interplay among NPCs, microglia, and developing vasculature. Thus, factors that impinge on any single component have the potential to change the trajectory of cortical development and increase susceptibility for altered neurodevelopmental outcomes.
机译：小胶质细胞与神经前体细胞（NPC）广泛接触，并与发育中大脑皮层的血管系统相关联。但脉管系统如何促进皮质组织发生尚不完全清楚。为了更好地理解胚胎大鼠大脑皮层血管系统发育的功能作用，我们研究了心室区血管、小胶质细胞和NPC之间的时间和空间关系。我们的结果表明，发育中的皮质血管中的内皮细胞延伸了许多直接接触有丝分裂NPC和小胶质细胞的精细过程；这些突起从血管壁突出，不同于尖端细胞突起；小胶质细胞、NPC和血管在心室附近高度相连。这些发现证明了NPC嵌入皮质增殖区的复杂环境，并表明发育中的脉管系统代表了一种可能广泛影响皮质发育的信号源。总之，皮质组织发生起源于NPC、小胶质细胞和发育中的血管系统之间的相互作用。因此，影响任何单一成分的因素都有可能改变皮质发育的轨迹，并增加改变神经发育结果的易感性。

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