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首页> 外文期刊>Journal of Applied Polymer Science >Antibiotic-loaded wound dressings obtained from the PBAT-gentamicin combination
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Antibiotic-loaded wound dressings obtained from the PBAT-gentamicin combination

机译：从PBAT-庆大霉素组合获得的抗生素负载伤口敷料

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The development of biodegradable curative systems containing antibacterial drug are fundamental for the promotion of therapeutic actions, reducing the infections caused by microorganisms and being able to substitute conventional dressings which are not biodegradable polymers in their composition. Meeting those needs, poly (butylene adipate-co-terephthalate) (PBAT) and PBAT/gentamicin (GT) fibers were electrospun using different concentrations of GT. The physical-chemical, morphological, thermal, antibacterial, and biological properties of the PBAT and PBAT/GT fibers were characterized. The presence of GT modified the mean diameter, roughness, and wettability of the prepared fibers. The degree of swelling was altered with the addition of GT. PBAT/GT fibers showed antibacterial activity against Escherichia coli strains reaching an inhibitory activity above 90% in the films with 2%, 5%, and 10% of GT. In addition, the fibers did not present cytotoxicity according to ISO 10993-5 standard. The obtained results reinforce that PBAT can be used as a curative system.
机译：含有抗菌药物的可生物降解治疗系统的开发对于促进治疗作用、减少微生物引起的感染以及能够替代其组成中不可生物降解聚合物的传统敷料至关重要。为了满足这些需求，聚己二酸丁二醇酯-对苯二甲酸乙二醇酯（PBAT）和PBAT/庆大霉素（GT）纤维采用不同浓度的GT进行静电纺丝。对PBAT和PBAT/GT纤维的物理化学、形态、热性能、抗菌性能和生物学性能进行了表征。GT的存在改变了所制备纤维的平均直径、粗糙度和润湿性。随着GT的加入，肿胀程度发生了改变。PBAT/GT纤维对大肠杆菌菌株的抗菌活性在GT含量为2%、5%和10%的薄膜中达到90%以上。此外，根据ISO 10993-5标准，纤维不具有细胞毒性。所得结果证实PBAT可以用作一种治疗系统。

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