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首页> 外文期刊>Journal of Applied Polymer Science >Preparation and characterization of ethanol-induced chitosan-glutaric anhydride hydrogel for biomedical applications
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Preparation and characterization of ethanol-induced chitosan-glutaric anhydride hydrogel for biomedical applications

机译：乙醇诱导的壳聚糖 - 戊二甲酸酐水凝胶的制备与表征生物医学应用

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摘要

Here we report a novel, fast, and facile sythesis of chitosan-based hydrogels by ethanol directly inducing. In the present of ethanol, chitosan (CS) with glutaric anhydride (GA) could form hydrogels (CS-GA-Hs) just in few minutes. The results of(1)H NMR and FTIR confirmed N-acylation substitution of chitosan. Furthermore, the relative concentration of GA was also the critical parameter for formation and properties of CS-GA-Hs. When the concentration was 1.5, CS-GA-Hs showed the highest swelling (253.6%) and release degree (99.9%). The porous structure of CS-GA-Hs were observed by SEM and the pore size of the gels decreased from 500 to 200 mu m, when the relative concentration of GA was changed from 1.5 to 4. And all the hydrogels were demonstrated a good mechanical properties. Additionally, the CS-GA-Hs showed in vitro antimicrobial activity againstStaphylococcus aureusandEscherichia coli, and no cytotoxicity toward L929 mouse fibroblasts, meaning it has potential applications in biomedical fields.
机译：本文报道了一种新型、快速、简便的乙醇直接诱导合成壳聚糖水凝胶的方法。在乙醇存在下，壳聚糖（CS）与戊二酸酐（GA）在几分钟内即可形成水凝胶（CS-GA-Hs）。核磁共振和红外光谱证实了壳聚糖的N-酰化取代。此外，GA的相对浓度也是CS-GA-Hs形成和性能的关键参数。当浓度为1.5时，CS-GA-Hs的溶胀度（253.6%）和释放度（99.9%）最高。扫描电镜观察了CS-GA-Hs的多孔结构，当GA的相对浓度从1.5改变到4时，凝胶的孔径从500μm减小到200μm。所有水凝胶均表现出良好的力学性能。此外，CS-GA-Hs对金黄色葡萄球菌和大肠杆菌具有体外抗菌活性，对L929小鼠成纤维细胞没有细胞毒性，这意味着它在生物医学领域具有潜在的应用前景。

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