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首页> 外文期刊>Journal of Applied Polymer Science >Facile fabrication of tough and biocompatible hydrogels from polyvinyl alcohol and agarose
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Facile fabrication of tough and biocompatible hydrogels from polyvinyl alcohol and agarose

机译：来自聚乙烯醇和琼脂糖的坚韧和生物相容性水凝胶的舒适性

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摘要

A polyvinyl alcohol (PVA)-agarose (agar) composite hydrogel (M-PVA-agar-60) was developed by simple three cycles of freeze-thawing, followed by successively soaking in ammonium sulfate aqueous solution to induce phase separation and dialyzing against deionized water to remove residual sulfate salts. Due to the synergy of crystalline regions, hydrogen bonding and phase separation domains, the obtained M-PVA-agar-60 hydrogel exhibits excellent mechanical properties (tensile strength = 1.1 MPa, tensile strain = 324% and compressive stress = 12.5 MPa), combined with a high water content of 87.0%. Moreover, the hydrogel hardly expands after immersing in the phosphate-buffered saline aqueous solution at 37 degrees C for a week, and the tensile stress and toughness remain almost the same as their initial values, superior to most reported non-swellable hydrogels. Because of the biocompatible starting materials, absence of toxic chemicals, and dialysis in advance to remove ammonium sulfate, the hydrogel also shows excellent cell compatibility, making it an ideal candidate for tissue engineering materials.
机译：通过简单的三个冻融循环，然后在硫酸铵水溶液中连续浸泡以诱导相分离，并用去离子水透析以去除残余硫酸盐，制备了聚乙烯醇（PVA）-琼脂糖（琼脂）复合水凝胶（M-PVA-琼脂-60）。由于结晶区、氢键和相分离域的协同作用，所获得的M-PVA-agar-60水凝胶具有优异的机械性能（拉伸强度=1.1 MPa，拉伸应变=324%，压缩应力=12.5 MPa），并具有87.0%的高含水量。此外，水凝胶在37℃的磷酸盐缓冲盐水溶液中浸泡一周后几乎不会膨胀，拉伸应力和韧性几乎与初始值相同，优于大多数报道的非膨胀水凝胶。由于起始材料具有生物相容性，不含有毒化学物质，并且可以提前透析以去除硫酸铵，水凝胶还显示出良好的细胞相容性，使其成为组织工程材料的理想候选材料。

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