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首页> 外文期刊>Journal of Applied Polymer Science >Enhanced properties of poly(epsilon-caprolactone)/polyvinylpyrrolidone electrospun scaffolds fabricated using 1,1,1,3,3,3-hexafluoro-2-propanol
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Enhanced properties of poly(epsilon-caprolactone)/polyvinylpyrrolidone electrospun scaffolds fabricated using 1,1,1,3,3,3-hexafluoro-2-propanol

机译：使用1,1,1,3,3,3-六氟-2-丙醇制造的聚（ε-己内酮）/聚乙烯吡咯烷酮电纺支架的增强性能

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摘要

Poly(epsilon-caprolactone)/polyvinylpyrrolidone (PCL/PVP) scaffolds with various composition were fabricated from 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) solution using the same electrospinning parameters in order to reveal the effect of polymer ratio on the material properties. The obtained materials were characterized using scanning electron microscopy, contact angle measurements, X-ray diffraction, Fourier-transformed infrared spectroscopy, and tensile testing. The strengthening effect of PVP was observed: Young modulus of PCL/PVP scaffold with 50/50 polymer ratio was found at 105.4 +/- 8.4 MPa which is six times higher comparing to those of PCL scaffold. PVP-containing scaffolds were extremely hydrophilic with PVP concentration of 5 wt% (vs. 25 wt% in previous reports) leading to full wetting of the material. in vitro studies showed an improved viability of HeLa cells cultured with the composites containing higher concentrations of PVP. Owing to the application of HFIP, PCL-based materials were loaded with cyclophosphamide for the first time and the PVP-containing materials demonstrated the intensified initial release of the model compound. Utilizing HFIP for the fabrication of PCL/PVP scaffolds significantly widens their application for drug delivery systems due to a good solubility of proteins, drugs, and other biologically active compounds in this solvent.
机译：以1,1,1,3,3,3-六氟-2-丙醇（HFIP）溶液为原料，采用相同的静电纺丝参数制备了不同组成的聚己内酯/聚乙烯吡咯烷酮（PCL/PVP）支架，以揭示聚合物比例对材料性能的影响。使用扫描电子显微镜、接触角测量、X射线衍射、傅里叶变换红外光谱和拉伸测试对所得材料进行了表征。观察到PVP的增强效果：50/50聚合物比的PCL/PVP支架的杨氏模量为105.4+/-8.4MPa，比PCL支架高六倍。含有PVP的支架非常亲水，PVP浓度为5%（之前的报告中为25%），导致材料完全润湿。体外研究表明，用含有较高浓度PVP的复合物培养的HeLa细胞的存活率提高。由于HFIP的应用，基于PCL的材料首次装载了环磷酰胺，含有PVP的材料显示了模型化合物的强化初始释放。由于蛋白质、药物和其他生物活性化合物在该溶剂中具有良好的溶解性，利用HFIP制备PCL/PVP支架大大拓宽了其在药物递送系统中的应用。

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