Highly filled poly(l-lactic acid)/hydroxyapatite composite for3Dprinting of personalized bone tissue engineering scaffolds

Dubinenko Gleb; Zinoviev Aleksey; Bolbasov Evgeny; Kozelskaya Anna; Shesterikov Evgeniy; Novikov Victor; Tverdokhlebov Sergei

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Highly filled poly(l-lactic acid)/hydroxyapatite composite for3Dprinting of personalized bone tissue engineering scaffolds

机译：高度填充的聚（L-乳酸）/羟基磷灰石复合材料，3dprinting个性化骨组织工程脚手架

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The designing of new biodegradable polymer composites is one of the most promising areas of modern orthopedics and regenerative surgery. At present, a number of methods have been proposed for designing and processing biodegradable polymer composites via various 3D printing technologies; however, the homogeneity of filler distribution together with mechanical properties of scaffolds made of such composites are far from those required for clinical use. In this study, the method for producing biodegradable composite material based on poly(l-lactic acid) (PLLA) solution in organic solvent and hydroxyapatite (HAp) powder was proposed. The influence of HAp weight fraction and additional annealing on PLLA matrix crystallinity was investigated. It was shown that crystallinity of PLLA decreases from 58.84 +/- 1.21 to 17.33 +/- 1.69 as HAp weight fraction increased from 0 to 50 wt%. However, HAp filler promoted PLLA crystallites growth according to the X-ray powder diffraction analysis. The results of nanoindentation showed Young's modulus values of the 3D-printed scaffolds with 50 wt% of HAp at the level of human femur and tibia.

机译：新型生物可降解聚合物复合材料的设计是现代骨科和再生外科最有前途的领域之一。目前，通过各种3D打印技术设计和加工生物可降解聚合物复合材料的方法已经被提出；然而，这种复合材料制成的支架的填充物分布均匀性和力学性能与临床使用要求相差甚远。本研究提出了在有机溶剂和羟基磷灰石（HAp）粉体中制备基于聚l-乳酸（PLLA）溶液的可生物降解复合材料的方法。研究了HAp质量分数和附加退火对PLLA基体结晶度的影响。结果表明，随着HAp重量分数从0%增加到50%，PLLA的结晶度从58.84+/-1.21降低到17.33+/-1.69。然而，根据X射线粉末衍射分析，HAp填料促进了PLLA微晶的生长。纳米压痕的结果显示，在人类股骨和胫骨水平上，含有50 wt%HAp的3D打印支架的杨氏模量值。

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来源
《Journal of Applied Polymer Science》 |2021年第2期|共10页
作者
Dubinenko Gleb; Zinoviev Aleksey; Bolbasov Evgeny; Kozelskaya Anna; Shesterikov Evgeniy; Novikov Victor; Tverdokhlebov Sergei;
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作者单位

Tomsk Polytech Univ 30 Lenin Ave Tomsk 634050 Russia;

Tomsk Polytech Univ 30 Lenin Ave Tomsk 634050 Russia;

Tomsk Polytech Univ 30 Lenin Ave Tomsk 634050 Russia;

Tomsk Polytech Univ 30 Lenin Ave Tomsk 634050 Russia;

RAS VE Zuev Inst Atmospher Opt SB Tomsk Russia;

Tomsk Polytech Univ 30 Lenin Ave Tomsk 634050 Russia;

Tomsk Polytech Univ 30 Lenin Ave Tomsk 634050 Russia;

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原文格式 PDF
正文语种 eng
中图分类高分子化合物工业（高聚物工业）;
关键词
biodegradable; biomedical applications; composites; extrusion; thermoplastics;

机译：可生物化的;生物医学应用;复合材料;挤出;热塑性塑料;

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2. Biologically Inspired Self-assembling Synthesis of Bone-like Nano-hydroxyapatite/PLGA- （PEG-ASP）n Composite： A New Biomimetic Bone Tissue Engineering Scaffold Material [J] . GUO, Xiaodong, YUAN, 武汉理工大学学报：材料科学英文版 . 2005,第B12期
3. Repair of radius defect with bone-morphogenetic-protein loaded hydroxyapatite/collagen-poly(L-lactic acid) composite [J] . 胡蕴玉, 张超, 吕荣, 中华创伤杂志（英文版） . 2003,第002期
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机译：用于骨组织工程的电纺聚（L-乳酸）/羟基磷灰石复合纤维支架
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机译：在高度多孔的聚（＃α＃-羟基酸）/羟基磷灰石复合支架上体外工程化新的骨组织
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机译：聚（L-乳酸）/羟基磷灰石纳米圆柱体作为骨组织工程支架的纳米纤维结构
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机译：骨质色组织工程构建与由聚（L-乳酸）/淀粉共混物制成的软骨部件和用于副骨的生物活性聚（L-乳酸）复合层制成
9. Hydroxyapatite/Poly(L-Lactic Acid) Fibrous Composites for Bone Tissue Engineering. [D] . Peng, Fei. 2011

机译：用于骨组织工程的羟基磷灰石/聚（L-乳酸）纤维复合材料。
10. Cytocompatibility of a conductive nanofibrous carbon nanotube/poly (L-Lactic acid) composite scaffold intended for nerve tissue engineering [O] . Mahboubeh Kabiri, Saeed Oraee-Yazdani, Masumeh Dodel, 2015

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11. Osteochondral Tissue Engineering Constructs with a Cartilage Part Made of Poly(L-Lactic Acid) / Starch Blend and a Bioactive Poly(L-Lactic Acid) Composite Layer for Subchondral Bone [O] . 2016

机译：骨软骨组织工程构建的软骨部分由聚（L-乳酸）/淀粉混合物和生物活性聚（L-乳酸）复合层为软骨下骨
12. Precipitation of Poly(L-Lactic Acid) and Composite Poly(L-Lactic Acid)-PyreneParticles by Rapid Expansion of Supercritical Solutions [R] . Tom, J. W., Debenedetti, P. G. 1994

机译：超临界溶液快速膨胀沉淀聚L-乳酸和复合聚L-乳酸 - 苯乙烯颗粒

Highly filled poly(l-lactic acid)/hydroxyapatite composite for3Dprinting of personalized bone tissue engineering scaffolds

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