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首页> 外文期刊>Journal of biomedical materials research, Part A >Design and fabrication of bone tissue scaffolds based onPCL/PHBV containinghydroxyapatite nanoparticles:dual-leachingtechnique
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Design and fabrication of bone tissue scaffolds based onPCL/PHBV containinghydroxyapatite nanoparticles:dual-leachingtechnique

机译：基于含羟基磷灰石纳米粒子的骨组织支架的设计与制作含羟基磷灰石纳米粒子：双lechingtechnique

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摘要

Scaffolds are the important part of the tissue-engineering field that are made from different biomaterials using various techniques. In this study, new scaffold based on polycaprolactone (PCL) and poly (hydroxybutyrate-co-hydroxyvalerate) (PHBV) containing hydroxyapatite nanopraticles (n-HA) were fabricated using the dual-leaching technique (DLT). Morphology, porosity, degradation rate, Fourier transfer infrared ray (FTIR) spectra, surface, and mechanical properties as well as capacity of cell binding and cell proliferation on the constructed scaffolds were evaluated. FTIR analysis showed that n-HA particles have some interest interactions with polymeric chains. The best 3D-structure was seen in PCL70PHBV30 scaffold using the scanning electron microscopy (SEM) and its structure improved in the presence of 3, 5 wt% of n-HA. Results of energy dispersive x-ray analysis (EDXA, map of Ca) showed that the nanoparticles have the uniform distribution within the fabricated scaffolds. Porosity analysis showed that the particulate salt leaching technique is a successful approach to building a 3D structure. Increasing of PHBV content and n-HA up to 3 and 5 wt% in the PCL matrix led to increase porosity in all samples. Mechanical properties analysis showed that values of compression modulus and strength are decreased with addition of PHBV and HA nanoparticles. These results were directly in line with the results of morphology and porosity. Cell culture experiments demonstrated that the PCL/PHBV/nHA nanocomposite scaffold has a better tendency of proliferation to cells than that of the pure PCL/PHBV scaffold. All of these results suggest promising potentials of the developed PCL/PHBV/nHA scaffolds in this study desire for bone tissue engineering.
机译：支架是组织工程领域的重要组成部分，由不同的生物材料通过各种技术制成。在本研究中，使用双浸取技术（DLT）制备了基于聚己内酯（PCL）和聚羟基丁酸-羟基戊酸共聚物（PHBV）的新型支架，其中含有羟基磷灰石纳米材料（n-HA）。评估了支架的形态、孔隙率、降解率、傅里叶变换红外光谱（FTIR）、表面和机械性能，以及细胞结合和细胞增殖能力。FTIR分析表明，n-HA颗粒与聚合物链之间存在一些有趣的相互作用。扫描电子显微镜（SEM）显示，PCL70PHBV30支架的三维结构最好，在3,5 wt%的n-HA存在下，其结构得到改善。能量色散x射线分析（EDXA，Ca图谱）的结果表明，纳米颗粒在所制备的支架内分布均匀。孔隙度分析表明，颗粒盐浸技术是构建三维结构的成功方法。PCL基质中PHBV含量和n-HA含量分别增加到3%和5%时，所有样品的孔隙率都会增加。力学性能分析表明，PHBV和HA纳米颗粒的加入降低了材料的压缩模量和强度。这些结果与形态学和孔隙度的结果直接一致。细胞培养实验表明，PCL/PHBV/nHA纳米复合支架比纯PCL/PHBV支架具有更好的细胞增殖倾向。所有这些结果表明，在本研究中开发的PCL/PHBV/nHA支架有望用于骨组织工程。

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