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首页> 外文期刊>Journal of Medicinal Chemistry >Tuberculosis: An Overview of the Immunogenic Response, Disease Progression, and Medicinal Chemistry Efforts in the Last Decade toward the Development of Potential Drugs for Extensively Drug-Resistant Tuberculosis Strains
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Tuberculosis: An Overview of the Immunogenic Response, Disease Progression, and Medicinal Chemistry Efforts in the Last Decade toward the Development of Potential Drugs for Extensively Drug-Resistant Tuberculosis Strains

机译：结核病：过去十年来概述了免疫原性反应，疾病进展和药用化学努力，旨在为广泛的耐药结核菌素菌株的潜在药物发展

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摘要

Tuberculosis (TB) is a slow growing, potentially debilitating disease that has plagued humanity for centuries and has claimed numerous lives across the globe. Concerted efforts by researchers have culminated in the development of various strategies to combat this malady. This review aims to raise awareness of the rapidly increasing incidences of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis, highlighting the significant modifications that were introduced in the TB treatment regimen over the past decade. A description of the role of pathogen-host immune mechanisms together with strategies for prevention of the disease is discussed. The struggle to develop novel drug therapies has continued in an effort to reduce the treatment duration, improve patient compliance and outcomes, and circumvent TB resistance mechanisms. Herein, we give an overview of the extensive medicinal chemistry efforts made during the past decade toward the discovery of new chemotypes, which are potentially active against TB-resistant strains.
机译：肺结核（TB）是一种生长缓慢、可能导致衰弱的疾病，数百年来一直困扰着人类，并在全球范围内夺走了无数生命。研究人员的共同努力最终导致了对抗这种疾病的各种策略的发展。本综述旨在提高人们对多药耐药（MDR）和广泛耐药（XDR）结核病发病率迅速增加的认识，重点介绍过去十年结核病治疗方案中引入的重大修改。讨论了病原体-宿主免疫机制的作用以及预防该疾病的策略。开发新型药物疗法的斗争仍在继续，以缩短治疗时间，提高患者依从性和疗效，并规避结核病耐药机制。在此，我们概述了过去十年中为发现新的化学类型所做的广泛的药物化学努力，这些化学类型可能对抗结核菌株具有活性。

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