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首页> 外文期刊>Journal of Medicinal Chemistry >Carbon-11: Radiochemistry and Target-Based PET Molecular Imaging Applications in Oncology, Cardiology, and Neurology
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Carbon-11: Radiochemistry and Target-Based PET Molecular Imaging Applications in Oncology, Cardiology, and Neurology

机译：碳-11：肿瘤，心脏病学和神经内科的放射化学和基于目标的PET分子成像应用

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摘要

The positron emission tomography (PET) molecular imaging technique has gained its universal value as a remarkable tool for medical diagnosis and biomedical research. Carbon-11 is one of the promising radiotracers that can report target-specific information related to its pharmacology and physiology to understand the disease status. Currently, many of the available carbon-11 (t(1/2) = 20.4 min) PET radiotracers are heterocyclic derivatives that have been synthesized using carbon-11 inserted different functional groups obtained from primary and secondary carbon-11 precursors. A spectrum of carbon-11 PET radiotracers has been developed against many of the upregulated and emerging targets for the diagnosis, prognosis, prediction, and therapy in the fields of oncology, cardiology, and neurology. This review focuses on the carbon-11 radiochemistry and various target-specific PET molecular imaging agents used in tumor, heart, brain, and neuroinflammatory disease imaging along with its associated pathology.
机译：正电子发射断层扫描（PET）分子成像技术已成为医学诊断和生物医学研究的重要工具，具有广泛的应用价值。碳-11是一种很有前途的放射性示踪剂，可以报告与其药理学和生理学相关的靶向信息，以了解疾病状态。目前，许多可用的碳-11（t（1/2）=20.4分钟）PET放射性示踪剂是杂环衍生物，它们是使用碳-11插入从初级和次级碳-11前体获得的不同官能团合成的。针对肿瘤学、心脏病学和神经学领域中许多上调和新兴的诊断、预后、预测和治疗靶点，已经开发出一系列碳-11 PET放射性示踪剂。本文综述了用于肿瘤、心脏、大脑和神经炎症疾病成像的碳-11放射化学和各种靶点特异性PET分子显像剂及其相关病理学。

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  • 来源
    《Journal of Medicinal Chemistry》 |2021年第3期|共37页
  • 作者

    Goud Nerella Sridhar; Bhattacharya Ahana; Joshi Raman Kumar; Nagaraj Chandana; Bharath Rose Dawn; Kumar Pardeep;

  • 作者单位

    Natl Inst Mental Hlth &

    Neuro Sci NIMHANS Dept Neuroimaging &

    Intervent Radiol NIIR Bengaluru 560029 India;

    Natl Inst Mental Hlth &

    Neuro Sci NIMHANS Dept Neuroimaging &

    Intervent Radiol NIIR Bengaluru 560029 India;

    Natl Inst Mental Hlth &

    Neuro Sci NIMHANS Dept Neuroimaging &

    Intervent Radiol NIIR Bengaluru 560029 India;

    Natl Inst Mental Hlth &

    Neuro Sci NIMHANS Dept Neuroimaging &

    Intervent Radiol NIIR Bengaluru 560029 India;

    Natl Inst Mental Hlth &

    Neuro Sci NIMHANS Dept Neuroimaging &

    Intervent Radiol NIIR Bengaluru 560029 India;

    Natl Inst Mental Hlth &

    Neuro Sci NIMHANS Dept Neuroimaging &

    Intervent Radiol NIIR Bengaluru 560029 India;

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  • 正文语种 eng
  • 中图分类 药学;
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