Breaking Oncogene Addiction: Getting RTK/RAS-Mutated Cancers off the SOS

Sheffels Erin; Kortum Robert L.

首页> 外文期刊>Journal of Medicinal Chemistry >Breaking Oncogene Addiction: Getting RTK/RAS-Mutated Cancers off the SOS

【24h】

Breaking Oncogene Addiction: Getting RTK/RAS-Mutated Cancers off the SOS

机译：打破癌基因成瘾：让RTK / RAS突变的癌症摆脱SOS

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

In RTK/RAS-mutated cancers, therapeutic resistance is driven by rebound activation of multiple RTKs; broad inhibition of RTK signaling can potentially delay therapeutic resistance for a majority of patients. A new SOS1 inhibitor, BI-3406, broadly inhibits proximal RTK signaling will greatly expand the efficacy of therapies used to treat RTK/RAS-mutated cancers.

机译：在RTK/RAS突变的癌症中，治疗耐药性是由多个RTK的反弹激活驱动的；广泛抑制RTK信号可能延迟大多数患者的治疗抵抗。一种新的SOS1抑制剂BI-3406广泛抑制近端RTK信号传导，将极大地提高治疗RTK/RAS突变癌症的疗效。

著录项

来源
《Journal of Medicinal Chemistry》 |2021年第10期|共3页
作者
Sheffels Erin; Kortum Robert L.;
展开▼
作者单位

Uniformed Serv Univ Hlth Sci Dept Pharmacol &

Mol Therapeut Bethesda MD 20814 USA;

Uniformed Serv Univ Hlth Sci Dept Pharmacol &

Mol Therapeut Bethesda MD 20814 USA;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药学;
关键词

相似文献

外文文献
中文文献
专利

1. Oncogene addiction and non-oncogene addiction in glioblastoma therapy [J] . Kimberly Ng, Clark C. Chen 中华医学杂志：英文版 . 2011,第017期
2. Oncogene addiction and non-oncogene addiction in glioblastoma therapy [J] . Kimberly Ng, Clark C.Chen 中华医学杂志（英文版） . 2011,第017期
3. Changes of oncogene DKK2 and SPOCK1 expression in bladder cancer lesions and their correlation with cancer cell proliferation and invasion [J] . Zhi-Yong Tuo, Xiu-Li Wei, Yong Xia 海南医科大学学报（英文版） . 2019,第003期
4. Changes of oncogene DKK2 and SPOCK1 expression in bladder cancer lesions and their correlation with cancer cell proliferation and invasion [J] . Zhi-Yong Tuo, Xiu-Li Wei, Yong Xia 海南医科大学学报(英文版) . 2019,第003期
5. Interplay between HSF1 and p53 signaling pathways in cancer initiation and progression: non-oncogene and oncogene addiction [J] . Toma-Jonik Agnieszka, Vydra Natalia, Janus Patryk, Cellular oncology . 2019,第5期

机译：HSF1和P53在癌症起始和进展中的信号传导途径之间的相互作用：非癌基因和癌基因成瘾
6. Oncogene addiction and immunity: clinical implications of tumour infiltrating lymphocytes in breast cancers overexpressing the HER2eu oncogene. [J] . Peter Savas, Franco Caramia, Zhi Ling Teo, Current Opinion in Oncology . 2014,第6期

机译：癌基因成瘾性和免疫力：过表达HER2 / neu癌基因的乳腺癌中肿瘤浸润淋巴细胞的临床意义。
7. Oncogene addiction and immunity: clinical implications of tumour infiltrating lymphocytes in breast cancers overexpressing the HER2/neu oncogene. [J] . Peter Savas, Franco Caramia, Zhi Ling Teo, Current Opinion in Oncology . 2014,第6期

机译：癌症成瘾和免疫：肿瘤浸润淋巴细胞在乳腺癌过度表达Her2 / Neu癌基因的临床意义。
8. Relevance of the Concept of Oncogene Addiction to Hormonal Carcinogenesis and Molecular Targeting in Cancer Prevention and Therapy [C] . Bernard Weinstei International Symposium on Hormonal Carcinogenesis . 2008

机译：癌症成瘾概念对癌症预防和治疗中激素致癌作用及分子靶向的相关性
9. A study of microRNA oncogene-addiction in lymphoma and microRNA radiosensitizers in lung cancer [D] . Babar, Imran Ali 2011

机译：肺癌淋巴瘤中微小RNA致癌基因的沉着和肺癌中微小RNA放射增敏剂的研究
10. Anti-c-Met monoclonal antibody ABT-700 breaks oncogene addiction in tumors with MET amplification [O] . Jieyi Wang, Liliane Goetsch, Lora Tucker, 2016

机译：抗c-Met单克隆抗体ABT-700通过MET扩增打破肿瘤中的癌基因成瘾
11. Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction [O] . Luo Ji, Solimini Nicole L., Elledge Stephen J. 2009

机译：癌症治疗原理：致癌基因和非致癌基因成瘾
12. RNASEH2A -- a Putative Non-Oncogene Addiction Gene Target and Marker for Radiosensitivity in High Risk Prostate Cancer. [R] . E. M. Schaeffer Z. Huang 2013

机译：RNasEH2a - 一种推定的非致癌基因成瘾基因靶标和高危前列腺癌放射敏感性标记物。

Breaking Oncogene Addiction: Getting RTK/RAS-Mutated Cancers off the SOS

摘要

著录项

相似文献

相关主题

期刊订阅