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首页> 外文期刊>Journal of Molecular Liquids >The solubility of Sulfabenzamide (an antibacterial drug) in supercritical carbon dioxide: Evaluation of a new thermodynamic model
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The solubility of Sulfabenzamide (an antibacterial drug) in supercritical carbon dioxide: Evaluation of a new thermodynamic model

机译：磺基苯胺（一种抗菌药物）在超临界二氧化碳中的溶解度：新热力学模型的评价

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摘要

Equilibrium solubilities of sulfabenzamide compound in supercritical carbon dioxide (ScCO2) have been explored at various pressures and temperatures. Solubilities measurements were carried using an equilibrium cell. Solubilities of sulfabenzamide reported were at four temperatures and at six pressures between (308 and 338) K and (12 and 27) MPa. The observed equilibrium solubilities were (1.53x10(-6) to 6.15x10(-6) at 308 K, 2.87x10(-6) to 8.98x10(-6) at 318 K, 6.15x10(-6) to 13.61x10(-6) at 328 K and 7.95x10(-6) to 22.35x10(-6) at 338 K). The measured saturation solubilities have been modeled with two new thermodynamic models based on solid-liquid equilibrium criteria. Moreover, Peng-Robinson's equation of state (PREoS) with Van der Walls mixing rules (VdWmr) and few other empirical solubility models have been explored. PREoS as temperature independent and Sodefian et al., models are quite good in predicting the data. From the correlation results it is clear that PREoS as temperature independent is able to correlate the data below 8.59% (corresponding AIC(c) is - 660.82). Among empirical models Sodefian et al., model is able to correlate the data below 8.24% (corresponding AIC(c) is -640.24). (C) 2021 Elsevier B.V. All rights reserved.
机译：研究了磺胺化合物在超临界二氧化碳（ScCO2）中在不同压力和温度下的平衡溶解度。溶解度测量使用平衡池进行。据报道，磺胺苯甲酰胺的溶解度在（308和338）K和（12和27）MPa之间的四个温度和六个压力下。观察到的平衡溶解度在308K时为（1.53x10（-6）至6.15x10（-6），在318K时为2.87x10（-6）至8.98x10（-6），在328K时为6.15x10（-6）至13.61x10（-6），在338K时为7.95x10（-6）至22.35x10（-6）。根据固液平衡准则，用两种新的热力学模型对测得的饱和溶解度进行了模拟。此外，彭-罗宾逊状态方程（PREoS）和范德瓦尔斯混合规则（VdWmr）以及其他一些经验溶解度模型也得到了探索。与温度无关的PREoS和Sodefian等人的模型在预测数据方面非常好。从相关结果可以明显看出，与温度无关的PREoS能够将低于8.59%的数据关联起来（相应的AIC（c）为-660.82）。在Sodefian等人的经验模型中，该模型能够关联低于8.24%的数据（对应的AIC（c）为-640.24）。（c）2021爱思唯尔B.V.保留所有权利。

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