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首页> 外文期刊>Journal of Molecular Biology >Molecular Strategies Underlying Porphyromonas gingivalis Virulence
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Molecular Strategies Underlying Porphyromonas gingivalis Virulence

机译：卟啉毒性毒性毒力的分子策略

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摘要

The anaerobic Gram-negative bacterium Porphyromonas gingivalis is considered the keystone of periodontitis diseases, a set of inflammatory conditions that affects the tissues surrounding the teeth. In the recent years, the major virulence factors exploited by P. gingivalis have been identified and characterized, including a cocktail of toxins, mainly proteases called gingipains, which promote gingival tissue invasion. These effectors use the Sec pathway to cross the inner membrane and are then recruited and transported across the outer membrane by the type IX secretion system (T9SS). In P. gingivalis, most secreted effectors are attached to anionic lipopolysaccharides (A-LPS), and hence form a virulence coat at the cell surface. P. gingivalis produces additional virulence factors to evade host immune responses, such as capsular polysaccharide, fimbriae and outer membrane vesicles. In addition to periodontitis, it is proposed that this broad repertoire of virulence factors enable P. gingivalis to be involved in diverse human diseases such as rheumatoid arthritis, and neurodegenerative, Alzheimer, and cardiovascular disorders. Here, we review the major virulence determinants of P. gingivalis and discuss future directions to better understand their mechanisms of action. (C) 2021 Elsevier Ltd. All rights reserved.
机译：厌氧革兰氏阴性菌牙龈卟啉单胞菌被认为是牙周炎疾病的关键，牙周炎是一组影响牙齿周围组织的炎症状态。近年来，牙龈假单胞菌所利用的主要毒力因子已被鉴定和表征，包括一种毒素混合物，主要是一种名为牙龈蛋白酶的蛋白酶，可促进牙龈组织入侵。这些效应器利用Sec途径穿过内膜，然后通过IX型分泌系统（T9SS）招募和运输穿过外膜。在牙龈假单胞菌中，大多数分泌效应物附着在阴离子脂多糖（A-LPS）上，因此在细胞表面形成毒力涂层。牙龈假单胞菌产生额外的毒力因子以逃避宿主免疫反应，如荚膜多糖、菌毛和外膜囊泡。除了牙周炎，有人提出，这种广泛的毒力因子使牙龈假单胞菌参与多种人类疾病，如类风湿性关节炎、神经退行性疾病、阿尔茨海默病和心血管疾病。在这里，我们回顾了牙龈假单胞菌的主要毒力决定因素，并讨论了进一步了解其作用机制的未来方向。（c）2021爱思唯尔有限公司保留所有权利。

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