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首页> 外文期刊>Analytical chemistry >Solvatochromic Study of Poly(vinyl chloride) Plasticizers and Their Solutions in Chloroform: Application to Phenobarbital Partitioning and Molecular Recognition of Phenobarbital
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Solvatochromic Study of Poly(vinyl chloride) Plasticizers and Their Solutions in Chloroform: Application to Phenobarbital Partitioning and Molecular Recognition of Phenobarbital

机译：聚氯乙烯增塑剂及其在氯仿中的溶液变色研究：在苯巴比妥分配和苯巴比妥分子识别中的应用

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The possibility now exists, with the availability of several families of artificial molecular receptors, to create selective extraction media. More selective extractions will lead to cleaner chromatograms, with lower detection limits and perhaps higher accuracy for trace organic analysis by chromatography. Furthermore, laboratories will be expected to minimize the use of volatile organic solvents. Consequently, nonvolatile, reusable solvents will be the basis for extractions. In addition, as artificial molecular receptors become more widely available, these solvents will be used to support molecular recognition. We have focused on plasticizers of poly(vinyl chloride) as examples of these solvents. We have determined solvatochromic parameters of several plasticizers and their solutions in chloroform. These parameters, along with cohesive energy density and solvent molar volume, were used to derive linear free energy relationships for the free energies of phenobarbital partitioning between solvent and aqueous solution, receptor solubility, formation of a complex with a barbiturate receptor [1,3-bis[[[6-(1-butyrylamino)pyrid-2-yl]amino]carbonyl]benzene (2)], and the transfer of the complex (artificial receptor and phenobarbital) from chloroform to other solvents. Solvent dipolarity/polarizability and hydrogen bond basicity, but not acidity, support complex dissociation. Solvents with large molar volumes dissolve the polar solutes, phenobarbital, receptor, and complex more poorly than solvents with lower molar volume, but there is no influence of molar volume on complex formation.
机译：现在，随着几种人工分子受体家族的存在，存在创造选择性提取介质的可能性。更具选择性的萃取将得到更清晰的色谱图，具有更低的检出限和更高的色谱法痕量有机物分析精度。此外，实验室有望减少挥发性有机溶剂的使用。因此，不挥发，可重复使用的溶剂将成为提取的基础。此外，随着人工分子受体的广泛使用，这些溶剂将用于支持分子识别。我们专注于聚氯乙烯的增塑剂作为这些溶剂的例子。我们已经确定了几种增塑剂及其在氯仿中的溶液的溶剂变色参数。这些参数，以及内聚能密度和溶剂摩尔体积，用于得出苯巴比妥在溶剂和水溶液之间分配的自由能，受体溶解度，与巴比妥酸酯受体形成复合物的线性自由能关系[1,3-双[[[[6-（1-丁酰基氨基）吡啶-2-基]氨基]羰基]苯（2）]，并将配合物（人工受体和苯巴比妥）从氯仿转移到其他溶剂中。溶剂的双极性/极化性和氢键碱性，而不是酸性，支持复合物解离。摩尔体积较大的溶剂比极性体积较小的溶剂溶解极性溶质，苯巴比妥，受体和配合物的能力更弱，但摩尔体积对复合物的形成没有影响。

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