rAAV9-UPII-TK-EGFP can precisely transduce a suicide gene and inhibit the growth of bladder tumors

Lian Foyan; Ye Qiang; Feng Bing; Cheng Hui; Niu Shaomin; Fan Ning; Wang Degui; Wang Zhiping

首页> 外文期刊>Cancer biology & therapy >rAAV9-UPII-TK-EGFP can precisely transduce a suicide gene and inhibit the growth of bladder tumors

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rAAV9-UPII-TK-EGFP can precisely transduce a suicide gene and inhibit the growth of bladder tumors

机译：RAAV9-UPII-TK-EGFP可以精确地转染自杀基因并抑制膀胱肿瘤的生长

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摘要

Bladder cancer is a common and widespread cancer of the human urinary system, and its incidence is increasing. Gene therapy is a promising treatment of bladder cancer. In our study, a recombinant adeno-associated virus (rAAV9-UPII-TK-EGFP) driven by a UPII promoter was constructed. The efficacy and safety of infection of bladder cells was tested in vivo and in vitro. The ability of rAAV9-UPII-TK-EGFP to penetrate the glycosaminoglycan (GAG) layer on the surface of bladder cells and to transduce the bladder cells in vivo was very high. Additionally, we confirmed that the TK/GCV system has a powerful cytotoxic effect on bladder tumor cells in vitro and in vivo. Thus, our data indicate that rAAV9-UPII-TK-EGFP is a precise gene drug delivery system for the treatment of bladder cancer, and the TK/GCV therapeutic strategy has a powerful antitumor effect. These ?ndings can be widely used in clinical and scientific studies.

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来源
《Cancer biology & therapy》 |2020年第12期|共8页
作者
Lian Foyan; Ye Qiang; Feng Bing; Cheng Hui; Niu Shaomin; Fan Ning; Wang Degui; Wang Zhiping;
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作者单位

Lanzhou Univ Inst Urol Dept Urol Key Lab Urol Dis Gansu Prov Hosp 2 Lanzhou Peoples R China;

Lanzhou Univ Inst Urol Dept Urol Key Lab Urol Dis Gansu Prov Hosp 2 Lanzhou Peoples R China;

Lanzhou Univ Inst Urol Dept Urol Key Lab Urol Dis Gansu Prov Hosp 2 Lanzhou Peoples R China;

Lanzhou Univ Inst Urol Dept Urol Key Lab Urol Dis Gansu Prov Hosp 2 Lanzhou Peoples R China;

Lanzhou Univ Inst Urol Dept Urol Key Lab Urol Dis Gansu Prov Hosp 2 Lanzhou Peoples R China;

Lanzhou Univ Inst Urol Dept Urol Key Lab Urol Dis Gansu Prov Hosp 2 Lanzhou Peoples R China;

Lanzhou Univ Sch Basic Med Sci Dept Anat &

Histol Lanzhou Peoples R China;

Lanzhou Univ Inst Urol Dept Urol Key Lab Urol Dis Gansu Prov Hosp 2 Lanzhou Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
Bladder cancer; gene therapy; glycosaminoglycan layer; suicide gene; adeno associated virus;

机译：膀胱癌;基因治疗;糖胺聚糖层;自杀基因;腺相关病毒;

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6. Efficient suicide gene therapy of transduced and distant untransduced ovary tumors is correlated with significant increase of intratumoral T and NK cells. [J] . Nagy HJ, Panis Y, Fabre M, Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie . 2000,第10期

机译：转导和远距离未转导的卵巢肿瘤的有效自杀基因治疗与肿瘤内T细胞和NK细胞的显着增加相关。
7. KMT2D inhibits the growth and metastasis of bladder Cancer cells by maintaining the tumor suppressor genes [J] . Sun Peng, Wu Tong, Sun Xiaoliang, Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie . 2019,第期

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11. Experimental therapy of allogeneic solid tumors induced in athymic mice with suicide gene-transducing replication-competent foamy virus vectors [O] . Martin Heinkelein, Ursula Hoffmann, Markus Lücke, 2005

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机译：冈田酸和蛋白磷酸酶1和2a的相关抑制剂在人乳腺肿瘤细胞中的分化，早期反应基因表达和凋亡诱导。冈田酸对人乳腺癌细胞的影响

rAAV9-UPII-TK-EGFP can precisely transduce a suicide gene and inhibit the growth of bladder tumors

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