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Clinical Characteristics and Outcomes in Patients with COVID-19 and Cancer: a Systematic Review and Meta-analysis

机译：Covid-19和癌症患者的临床特征和结果：系统评价和荟萃分析

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摘要

Much of routine cancer care has been disrupted due to the perceived susceptibility to SARS-CoV-2 infection in cancer patients. Here, we systematically review the current evidence base pertaining to the prevalence, presentation and outcome of COVID-19 in cancer patients, in order to inform policy and practice going forwards. A keyword-structured systematic search was conducted on Pubmed, Cochrane, Embase and MedRxiv databases for studies reporting primary data on COVID-19 in cancer patients. Studies were critically appraised using the NIH National Heart, Lung and Blood Institute's quality assessment tool set. The pooled prevalence of cancer as a co-morbidity in patients with COVID-19 and pooled in-hospital mortality risk of COVID-19 in cancer patients were derived by random-effects meta-analyses. In total, 110 studies from 10 countries were included. The pooled prevalence of cancer as a co-morbidity in hospitalised patients with COVID-19 was 2.6% (95% confidence interval 1.8%, 3.5%, I-2 : 92.0%). Specifically, 1.7% (95% confidence interval 1.3%, 2.3%, I-2 : 57.6.%) in China and 5.6% (95% confidence interval 4.5%, 6.7%, I-2 : 82.3%) in Western countries. Patients most commonly presented with non-specific symptoms of fever, dyspnoea and chest tightness in addition to decreased arterial oxygen saturation, ground glass opacities on computer tomography and non-specific changes in inflammatory markers. The pooled in-hospital mortality risk among patients with COVID-19 and cancer was 14.1% (95% confidence interval 9.1%, 19.8%, I-2 : 52.3%). We identified impeding questions that need to be answered to provide the foundation for an iterative review of the developing evidence base, and inform policy and practice going forwards. Analyses of the available data corroborate an unfavourable outcome of hospitalised patients with COVID-19 and cancer. Our findings encourage future studies to report detailed social, demographic and clinical characteristics of cancer patients, including performance status, primary cancer type and stage, as well as a history of anti-cancer therapeutic interventions. (C) 2020 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
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著录项

  • 来源
    《Clinical oncology》 |2021年第3期|共12页
  • 作者

    Zarifkar P.; Kamath A.; Robinson C.; Morgulchik N.; Shah S. F. H.; Cheng T. K. M.; Dominic C.; Fehintola A. O.; Bhalla G.; Ahillan T.; dAlgue L. Mourgue; Lee J.; Pareek A.; Carey M.; Hughes D. J.; Miller M.; Woodcock V. K.; Shrotri M.;

  • 作者单位

    Aarhus Univ Hosp Dept Nucl Med Palle Juul Jensens Blvd 161 DK-8200 Aarhus C Denmark;

    Univ Oxford Fac Med John Radcliffe Hosp Med Sci Div Off Oxford England;

    Univ Oxford Fac Med John Radcliffe Hosp Med Sci Div Off Oxford England;

    Imperial Coll London Dept Chem Mol Sci Res Hub London England;

    Univ Cambridge Sch Clin Med Cambridge England;

    Univ Cambridge Sch Clin Med Cambridge England;

    Queen Mary Univ London Barts &

    London Sch Med London England;

    Univ Ibadan Coll Med Ibadan Nigeria;

    Queen Mary Univ London Barts &

    London Sch Med London England;

    UCL Med Sch London England;

    UCL Fac Life Sci London England;

    Univ Oxford Nuffield Dept Primary Care Hlth Sci Oxford England;

    Stanford Univ Sch Med Dept Radiol Stanford CA USA;

    Oxford Univ Hosp NHS Fdn Trust Churchill Hosp Dept Palliat Care Sobell House Hosp Oxford;

    Kings Coll London Sch Biomed Engn &

    Imaging Sci Dept Canc Imaging London England;

    Oxford Univ Hosp NHS Fdn Trust Churchill Hosp Dept Palliat Care Sobell House Hosp Oxford;

    Oxford Univ Hosp NHS Trust Churchill Hosp Dept Oncol Oxford England;

    London Sch Hyg &

    Trop Med London England;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 肿瘤学;
  • 关键词

    Cancer; COVID-19; mortality; prevalence; SARS-CoV-2; systematic review;

    机译：癌症;Covid-19;死亡率;患病率;SARS-COV-2;系统评论;

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