Evidence-based best practice advice for patients treated with systemic immunosuppressants in relation to COVID-19

Galimberti Fabrizio; McBride Jeffrey; Cronin Megan; Li Yumeng; Fox Joshua; Abrouk Michael; Herbst Alexander; Kirsner Robert S.

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Evidence-based best practice advice for patients treated with systemic immunosuppressants in relation to COVID-19

机译：基于证据的最佳实践建议，用于患有Covid-19的全身免疫抑制剂治疗的患者

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The emergence of the COVID-19 pandemic has led to significant uncertainty among physicians and patients about the safety of immunosuppressive medications used for the management of dermatologic conditions. We review available data on commonly used immunosuppressants and their effect on viral infections beyond COVID-19. Notably, the effect of some immunosuppressants on viruses related to SARS-CoV2, including SARS and MERS, has been previously investigated. In the absence of data on the effect of immunosuppressants on COVID-19. these data could be used to make clinical decisions on initiation and continuation of immunosuppressive medications during this pandemic. In summary, we recommend considering the discontinuation of oral Janus kinase (JAK) inhibitors and prednisone; considering the delay of rituximab infusion; and suggesting the careful continuation of cyclosporine, mycophenolate, azathioprine, methotrexate. and biologics in patients currently benefitting from such treatments. (C) 2020 Published by Elsevier Inc.

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《Clinics in dermatology》 |2020年第6期|共6页
作者
Galimberti Fabrizio; McBride Jeffrey; Cronin Megan; Li Yumeng; Fox Joshua; Abrouk Michael; Herbst Alexander; Kirsner Robert S.;
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Univ Miami Miller Sch Med Dr Phillip Frost Dept Dermatol &

Cutaneous Surg Miami FL 33136 USA;

Univ Miami Miller Sch Med Dr Phillip Frost Dept Dermatol &

Cutaneous Surg Miami FL 33136 USA;

Univ Miami Miller Sch Med Dr Phillip Frost Dept Dermatol &

Cutaneous Surg Miami FL 33136 USA;

Univ Miami Miller Sch Med Dr Phillip Frost Dept Dermatol &

Cutaneous Surg Miami FL 33136 USA;

Univ Miami Miller Sch Med Dr Phillip Frost Dept Dermatol &

Cutaneous Surg Miami FL 33136 USA;

Univ Miami Miller Sch Med Dr Phillip Frost Dept Dermatol &

Cutaneous Surg Miami FL 33136 USA;

Univ Miami Miller Sch Med Dr Phillip Frost Dept Dermatol &

Cutaneous Surg Miami FL 33136 USA;

Univ Miami Miller Sch Med Dr Phillip Frost Dept Dermatol &

Cutaneous Surg Miami FL 33136 USA;

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正文语种 eng
中图分类皮肤病学与性病学;
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Evidence-based best practice advice for patients treated with systemic immunosuppressants in relation to COVID-19

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