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Spectrophotometric and conductometric determination of propranolol as Mg(II), Pb(II), Fe(II), Mn(II) and Ni(II)-dithiocarbamate complexes

机译:分光光度法和电导法测定普萘洛尔作为Mg(II),Pb(II),Fe(II),Mn(II)和Ni(II)-二硫代氨基甲酸酯配合物的含量

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A spectrophotometric method was developed for the determination of the beta adrenergic blocking drug propranolol. The method was based on the formation of Mg(II), Pb(II), Fe(II), Mn(II) and Ni(II)-dithiocarbamate complexes from the secondary amine group of propranolol with carbondisulfide (CS2) and the acetate salts of the metals in ammonia medium, and The interaction of the Propranolol with Pb(C2H3O2)2, Mg(CH3COO)2, Mn(CH3COO)2, C_(14)H_(27)Fe3O_(18) C4H6NiO4 in methanol has been investigated by conductometric method under equilibrium conditions1"6. The stability constants of the complexes were determined using a GENPLOT computer program7. The conductance data and Absorbance— mole ratio plots show mat in all solvent systems, the stochiometric of the complexes formed between Propranolol and Mg(II), Pb(II), Fe(II), Mn(II) and Ni(II) cations is 1:1 (M:L). The obtained results show that the stability of Mg(II)-Pr, Pb(H)-Pr, Fe(II)-Pr, Mn(II)-Pr and Ni(II)-Pr complexes is sensitive to die mixed solvents composition. The values of mermody-namic parameters (AG°, AH0 and AS°) for formation of Mg(II)-Pr, Pb(II)-Pr, Fe(II)-Pr, Mn(II)-Pr and Ni(II)-Pr complexes were obtained from temperature dependence of the stability constant using the van't Hoff plots. The value of logkf calculated from the absorption spectra measurement for Mg(II)-Pr, Pb(II)-Pr, Fe(II)-Pr, Mn(II)-Pr and Ni(II)-Pr complexes at 25UC. The results show that the complexation formation is affected by the nature of solvents
机译:开发了一种用于测定β肾上腺素阻断药普萘洛尔的分光光度法。该方法基于普萘洛尔的仲胺基与二硫化碳(CS2)和乙酸盐形成的Mg(II),Pb(II),Fe(II),Mn(II)和Ni(II)-二硫代氨基甲酸酯配合物氨介质中金属的盐和丙醇在甲醇中与Pb(C2H3O2)2,Mg(CH3COO)2,Mn(CH3COO)2,C_(14)H_(27)Fe3O_(18)C4H6NiO4的相互作用为在平衡条件1“ 6下通过电导测定方法进行了研究。使用GENPLOT计算机程序7确定了络合物的稳定性常数。电导数据和吸光度-摩尔比图显示了所有溶剂系统中的物质,普萘洛尔和镁之间形成的络合物的化学计量(II),Pb(II),Fe(II),Mn(II)和Ni(II)阳离子为1:1(M:L),所得结果表明Mg(II)-Pr,Pb的稳定性(H)-Pr,Fe(II)-Pr,Mn(II)-Pr和Ni(II)-Pr配合物对混合溶剂的组成敏感。商品自然参数(AG°,AH0和AS°)的值)形成Mg(II)-Pr,使用van't Hoff图根据稳定性常数的温度依赖性获得Pb(II)-Pr,Fe(II)-Pr,Mn(II)-Pr和Ni(II)-Pr配合物。由Mg(II)-Pr,Pb(II)-Pr,Fe(II)-Pr,Mn(II)-Pr和Ni(II)-Pr络合物在25UC下的吸收光谱测量得出的logkf值。结果表明,络合物的形成受溶剂性质的影响

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