Increased IL-6 and Potential IL-6 trans-signalling in the airways after an allergen challenge

Esnault Stephane; Khosravi Mehdi; Kelly Elizabeth A.; Liu Lin Ying; Bochkov Yury A.; Tattersall Matthew C.; Jarjour Nizar N.

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Increased IL-6 and Potential IL-6 trans-signalling in the airways after an allergen challenge

机译：在过敏原挑战后，在气道中增加IL-6和潜在的IL-6转运信号

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Background In asthma, IL-6 is a potential cause of enhanced inflammation, tissue damage and airway dysfunction. IL-6 signalling is regulated by its receptor, which is composed of two proteins, IL-6R and GP130. In addition to their membrane form, these two proteins may be found as extracellular soluble forms. The interaction of IL-6 with soluble IL-6R (sIL-6R) can trigger IL-6 trans-signalling in cells lacking IL-6R. Conversely, the soluble form of GP130 (sGP130) competes with its membrane form to inhibit IL-6 trans-signalling.

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来源
《Clinical and experimental allergy :》 |2021年第4期|共10页
作者
Esnault Stephane; Khosravi Mehdi; Kelly Elizabeth A.; Liu Lin Ying; Bochkov Yury A.; Tattersall Matthew C.; Jarjour Nizar N.;
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作者单位

Univ Wisconsin Dept Med Div Allergy Pulm &

Crit Care Med Sch Med &

Publ Hlth Madison WI USA;

Univ Wisconsin Dept Med Div Allergy Pulm &

Crit Care Med Sch Med &

Publ Hlth Madison WI USA;

Univ Wisconsin Dept Med Div Allergy Pulm &

Crit Care Med Sch Med &

Publ Hlth Madison WI USA;

Univ Wisconsin Dept Med Div Allergy Pulm &

Crit Care Med Sch Med &

Publ Hlth Madison WI USA;

Univ Wisconsin Dept Pediat Sch Med &

Publ Hlth Madison WI USA;

Univ Wisconsin Dept Med Div Cardiovasc Med Sch Med &

Publ Hlth Madison WI USA;

Univ Wisconsin Dept Med Div Allergy Pulm &

Crit Care Med Sch Med &

Publ Hlth Madison WI USA;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
allergy; asthma; bronchoalveolar lavage; CCL2; fibroblasts; IL-6; IL-6 receptor; trans-signalling;

机译：过敏;哮喘;支气管肺泡灌洗;CCL2;成纤维细胞;IL-6;IL-6受体;跨信令;

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1. DNA vaccine encoding Der p2 allergen down-regulates STAT6 expression in mouse model of allergen-induced allergic airway inflammation [J] . 中华医学杂志（英文版） . 2006,第003期
2. DNA vaccine encoding Der p 2 allergen generates immunologic protection in recombinant Der p 2 allergen-induced allergic airway inflammation mice model [J] . LI Guo-ping, LIU Zhi-gang, QIU Jing, 中华医学杂志（英文版） . 2005,第007期
3. HMGB1 contributes to allergen-induced airway remodeling in a murine model of chronic asthma by modulating airway inflammation and activating lung fibroblasts [J] . Changchun Hou, Jinliang Kong, Yue Liang, 中国免疫学杂志（英文版） . 2015,第004期
4. HMGB 1 contributes to allergen-induced airway remodeling in a murine model of chronic asthma by modulating airway inflammation and activating lung fibroblasts [J] . Changchun H ou, Jinliang Kong, Yue Liang, 细胞与分子免疫学：英文版 . 2015,第004期
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机译：过敏原诱导的IL-6调节过敏性气道炎症中CD4 + T细胞中的IL-9 / IL-17A平衡
6. Allergen-Induced IL-6 Regulates IL-9/IL-17A Balance in CD4(+) T Cells in Allergic Airway Inflammation [J] . Schuetze Nicole, Trojandt Stefanie, Kuhn Stephanie, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2016,第7期

机译：过敏原IL-6调节过敏气道炎症中CD4（+）T细胞中的IL-9 / IL-17A平衡
7. Allergen-induced IL-6 trans-signaling activates gamma delta T cells to promote type 2 and type 17 airway inflammation [J] . Ullah Md Ashik, Revez Joana A., Loh Zhixuan, The Journal of Allergy and Clinical Immunology . 2015,第4期

机译：过敏原诱导的IL-6反信号激活γ-δT细胞，促进2型和17型气道炎症
8. Nrf2 induces IL-6 expression via an antioxidant response element within the IL-6 promoter [C] . C.J. Wruck, M.E. Gotz, M. Tohidnezhad, Europe Meeting of the Society for Free Radical Research . 2009

机译：NRF2通过IL-6启动子内的抗氧化剂反应元件诱导IL-6表达
9. Systemic levels of G-CSF and IL-6 determine the angiogenic potential of bone marrow resident monocytes. [D] . Gregory, Alyssa Diane. 2009

机译：G-CSF和IL-6的全身水平决定了骨髓驻留单核细胞的血管生成潜力。
10. IL-6 is required for airway mucus production induced by inhaled fungal allergens [O] . Wendy A. Neveu, Jenna B. Allard, Oliver Dienz, -1

机译：吸入真菌过敏原诱导的气道粘液生产需要IL-6
11. Decreased Expression of Membrane IL-5 Receptor α on Human Eosinophils: I. Loss of Membrane IL-5 Receptor α on Airway Eosinophils and Increased Soluble IL-5 Receptor α in the Airway After Allergen Challenge [O] . Lin Ying Liu, Julie B. Sedgwick, Mary Ellen Bates, 2002

机译：减少膜IL-5受体α对人嗜酸性粒细胞的表达：I。过敏原攻击后气道嗜酸性粒细胞的膜IL-5受体α的损失和在气道内增加可溶性IL-5受体α
12. Neutralization Effects of Interleukin-6 (IL-6) Antibodies on Sulfur Mustard (HD)-Induced IL-6 Secretion on Human Epidermal Keratinocytes [R] . Arroyo, C. M. , Burman, D. L. , Sweeney, R. E. , 2004

机译：白细胞介素-6（IL-6）抗体对硫芥（HD）诱导的人表皮角质形成细胞IL-6分泌的中和作用

Increased IL-6 and Potential IL-6 trans-signalling in the airways after an allergen challenge

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