Reprint of: Role of O-linked N-acetylglucosamine (O-GlcNAc) modification of proteins in diabetic cardiovascular complications

Chatham John C.; Young Martin E.; Zhang Jianhua

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Reprint of: Role of O-linked N-acetylglucosamine (O-GlcNAc) modification of proteins in diabetic cardiovascular complications

机译：转载：O-连接的N-乙酰葡糖胺（O-GLCNAC）改性蛋白质糖尿病心血管并发症的作用

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The post-translational modification of serine and threonine residues of proteins by O-linked N-acetylglucosamine (O-GlcNAc) regulates diverse cellular processes in the cardiovascular system. UDP-GlcNAc is a substrate for O-GlcNAc transferase, which catalyzes the attachment of O-GlcNAc to proteins. O-GlcNAcase catalyzes the removal of O-GlcNAc from proteins. UDP-GlcNAc is the end product of the hexosamine biosynthesis pathway, which is regulated primarily by glucose-6-phosphate-Glutamine:fructose-6-phosphate amidotransferase (GFAT). GFAT catalyzes the formation of glucosamine-6-phosphate from fructose-6-phosphate and glutamine. Whereas O-GlcNAc is essential for cell viability, sustained increases in O-GlcNAc levels have been implicated in the etiology of many chronic diseases and is associated with glucose toxicity and diabetic complications in various organs including the cardiovascular system. This review provides an overview of the regulation of protein O-GlcNAcylation followed by a discussion of potential mechanisms by which dysregulation in O-GlcNAc cycling contributes to the adverse effects of diabetes on the cardiovascular system.

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《Current opinion in pharmacology》 |2020年第1期|共12页
作者
Chatham John C.; Young Martin E.; Zhang Jianhua;
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Univ Alabama Birmingham Dept Pathol Div Mol &

Cellular Pathol Birmingham AL 35294 USA;

Univ Alabama Birmingham Dept Med Div Cardiovasc Dis Birmingham AL 35294 USA;

Univ Alabama Birmingham Dept Pathol Div Mol &

Cellular Pathol Birmingham AL 35294 USA;

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正文语种 eng
中图分类药理学;
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5. Role of O-linked N-acetylglucosamine (O-GlcNAc) modification of proteins in diabetic cardiovascular complications [J] . Chatham John C., Young Martin E., Zhang Jianhua Current opinion in pharmacology . 2021,第1期

机译：O-连接的N-乙酰葡糖胺（O-GLCNAC）改性蛋白质在糖尿病心血管并发症中的作用
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机译：O-连接的N-乙酰氨基葡萄糖在糖尿病伴发糖尿病大鼠各种组织中的蛋白质翻译后修饰升高。
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机译：蛋白质组学生物标志物发现糖尿病并发症：仙人掌研究中的尿蛋白谱
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机译：靶向乳腺癌中的蛋白质O-GlcNac修饰

Reprint of: Role of O-linked N-acetylglucosamine (O-GlcNAc) modification of proteins in diabetic cardiovascular complications

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