N-methyl-D-aspartate receptor function in neuronal and synaptic development and signaling

Pagano Jessica; Giona Federica; Beretta Stefania; Verpelli Chiara; Sala Carlo

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N-methyl-D-aspartate receptor function in neuronal and synaptic development and signaling

机译：N-甲基-D-天冬氨酸受体功能在神经元和突触发育和信号传导中

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The N-methyl-D-aspartate (NMDA) receptor, among the ionotropic glutamate receptors, are fundamental to integrating and transducing complex signaling in neurons. Glutamate activation of these receptors mediates intracellular signals essential to neuronal and synaptic formation and synaptic plasticity and also contribute to excitotoxic processes in several neurological disorders. The NMDA receptor signaling is mediated by the permeability to Ca2+ and by the large network of signaling and scaffolding proteins associated mostly with the large C -terminal domain of GluN2 subunits. Important studies showed that GluN2 C-terminal interactions differ in accordance with the GluN2 subtype, and this influences the type of signaling that NMDA receptor activity controls. Thus, it is not surprising that mutations in genes that codify for NMDA receptor subunits have been associated with severe neuronal diseases. We will review recent advances and explore outstanding problems in this active area of research.

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《Current opinion in pharmacology》 |2021年第1期|共9页
作者
Pagano Jessica; Giona Federica; Beretta Stefania; Verpelli Chiara; Sala Carlo;
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CNR Neurosci Inst Milan Italy;

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正文语种 eng
中图分类药理学;
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6. In developing hippocampal neurons, NR2B-containing N-methyl-D-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death. [J] . Martel MA, Wyllie DJ, Hardingham GE Neuroscience: An International Journal under the Editorial Direction of IBRO . 2009,第1期

机译：在发育中的海马神经元中，含有NR2B的N-甲基-D-天冬氨酸受体（NMDARs）可以介导神经元存活和突触增强以及神经元死亡的信号传导。
7. N-methyl-D-aspartate receptor subunit- and neuronal-type dependence of excitotoxic signaling through post-synaptic density 95. [J] . Fan J, Vasuta OC, Zhang LY, Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry . 2010,第4期

机译：N-甲基-D-天门冬氨酸受体通过突触后密度95引起的兴奋毒性信号传导的亚基和神经元类型依赖性。
8. Involvement of the GluN2A and GluN2B Subunits in Synaptic and Extrasynaptic N-methyl-d-aspartate Receptor Function and Neuronal Excitotoxicity [J] . Xianju Zhou, Qi Ding, Zhuoyou Chen, The Journal of biological chemistry . 2013,第33期

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11. Involvement of the GluN2A and GluN2B Subunits in Synaptic and Extrasynaptic N-methyl-d-aspartate Receptor Function and Neuronal Excitotoxicity [O] . Xianju Zhou, Qi Ding, Zhuoyou Chen, 2013

机译：GluN2A和GluN2B亚基参与突触和突触N-甲基-d-天冬氨酸受体功能和神经元兴奋性。
12. In developing hippocampal neurons, NR2B-containing N-methyl-d-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death [O] . Martel, M.-A., Wyllie, D.J.A., Hardingham, G.E. 2009

机译：在开发海马神经元中，含NR2B的N-甲基-d-天冬氨酸受体（NmDaRs）可介导神经元存活和突触增强以及神经元死亡的信号传导。
13. Novel Functions of NF-kappaB2/p52 in Androgen Receptor Signaling in CRPC. [R] . Nadiminty, N. 2015

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N-methyl-D-aspartate receptor function in neuronal and synaptic development and signaling

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