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Structuring of composite hydrogel bioadhesives and its effect on properties and bonding mechanism

机译：复合水凝胶生物粘附的构建及其对性能和粘合机制的影响

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摘要

Graphical abstract A schematic representation of a qualitative model describing the effects of the bioadhesive components on the cohesive and adhesive strength. The blue/red arrows represent a case where an increase/decrease, respectively, in a certain parameter results in an increase in the following one. Dashed lines represent a more moderate response. Display Omitted Abstract Bioadhesives are polymeric hydrogels that can adhere to a tissue after crosslinking and are an essential element in nearly all surgeries worldwide. Several bioadhesives are commercially available. However, none of them are ideal. The main limitation of current tissue adhesives is the tradeoff between biocompatibility and mechanical strength, especially in wet hemorrhagic environments. Our novel bioadhesives are based on the natural polymers gelatin (coldwater fish) and alginate, crosslinked by carbodiimide (EDC). Two types of hemostatic agents with a layered silicate structure, montmorillonite (MMT) and kaolin, were loaded in order to improve the sealing ability in a hemorrhagic environment. The effect of the adhesive's components on its mechanical strength was studied by three different methods – burst strength, lap shear and compression. The viscosity, gelation time and structural features of the adhesive were also studied. A qualitative model that describes the effect of the bioadhesive’s parameters on the cohesive and adhesive strength was developed. A formulation based on 400 mg/mL gelatin, 10 mg/mL alginate and 20 mg/mL EDC was found as optimal, enabling a burst strength of 387 mmHg. Incorporation of kaolin increased the burst strength by 25% due to microcomposite structuring, whereas MMT increased the burst strength by 50% although loaded in a smaller concentration, due to nano-structuring effects. This research clearly shows that the incorporation of kaolin and MMT in gelatin-alginate surgical sealants is a very promising novel approach for improving the bonding strength and physical properties of surgical sealants for use in hemorrhagic environments. Statement of Significance The current manuscript focuses on novel bioadhesives, based on natural polymers and loaded with hemostatic agents with a layered silicate structure, in order to improve the sealing ability in hemorrhagic environment. Such composite bioadhesives have not been developed and studied before. The effect of the adhesive's components on its mechanical strength was studied by three different methods, as well as the physical properties and structural features. Thorough understanding of these unique biomaterials resulted in a qualitative model which describes the effect of the bioadhesive’s parameters on the cohesive and adhesive strength. Thus, structure-property-function relationships are presented. Structuring of the composite bioadhesives and its effect of the properties and bonding mechanism, are expected to be of high interest to Acta readership.
机译：None

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  • 来源
    《Acta biomaterialia》 |2017年第1期|共13页
  • 作者

    Oded Pinkas; Daniella Goder; Roni Noyvirt; Sivan Peleg; Maayan Kahlon; Meital Zilberman;

  • 作者单位

    Dept. of Materials Science and Engineering Faculty of Engineering Tel-Aviv University;

    Dept. of Biomedical Engineering Faculty of Engineering Tel-Aviv University;

    Dept. of Biomedical Engineering Faculty of Engineering Tel-Aviv University;

    Dept. of Biomedical Engineering Faculty of Engineering Tel-Aviv University;

    Dept. of Biomedical Engineering Faculty of Engineering Tel-Aviv University;

    Dept. of Materials Science and Engineering Faculty of Engineering Tel-Aviv University;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 普通生物学;
  • 关键词

    Tissue adhesives; Kaolin; Montmorillonite;

    机译：组织粘合剂;高岭土;蒙脱石;

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