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Bio-inspired virus imprinted polymer for prevention of viral infections

机译：生物启发的病毒印迹聚合物用于预防病毒感染

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摘要

Graphical abstract Display Omitted Abstract A novel virus-imprinted polymer for prevention of viral infection was prepared by anchoring molecularly imprinted polymer (MIP) on the surface of poly-dopamine (PDA)-coated silica particles. The imprinting reaction was carried out via self-polymerization of dopamine in the presence of a virus template. Plaque forming assay indicated that the MIP exhibited selective anti-viral infection properties for the template virus in complex media containing different interfering substances, and even other types of viruses. Remarkable dose-dependent and time-dependent inhibition of virus infection was observed due to the MIP’s selective binding to the template virus. When the MIP was incubated with the virus and host cells together, rapid and selective adsorption of template viruses by the MIP prevented the viruses to infect the host cells in a period of 12 h. The MIP was biocompatible and non-toxic, and had excellent stability and reusability. Furthermore, the MIPs prepared using different viruses as templates showed similar anti-viral infection properties. The MIP synthesized using dopamine as monomer and crude virus as template provided an attractive possibility for clinical applications in the field of antiviral therapy. Statement of Significance This is the first report to prepare artificial antibody (molecularly imprinted polymer, MIP) that can selectively prevent virus infection using dopamine self-polymerization system. Only MIP anchoring on the surface of poly-dopamine coated silica particles and polymerized using ammonium persulfate as radical initiator showed dose-dependent and time-dependent inhibition of template virus infection in complex media containing interferences and even other viruses. Viruses bond to MIP lost infectious capability. When incubated with virus and host cells, MIP rebond viruses rapidly and selectively to prevent viruses infecting host cells for 12 h. The achieved MIPs were biocompatibility, non-toxicity with excellent stability and reusability, and can be used to different viruses. The bio-mimic MIPs provided an attractive prospect for clinical applications in antiviral therapy.
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著录项

  • 来源
    《Acta biomaterialia》 |2017年第1期|共9页
  • 作者

    Ning Li; Yan-jie Liu; Fei Liu; Mi-fang Luo; Ying-chun Wan; Zheng Huang; Qiang Liao; Fang-sheng Mei; Zhi-cheng Wang; Ai-yin Jin; Yun Shi; Bin Lu;

  • 作者单位

    Key Laboratory of Environment and Health Ministry of Education &

    Ministry of Environmental;

    Key Laboratory of Environment and Health Ministry of Education &

    Ministry of Environmental;

    Key Laboratory of Environment and Health Ministry of Education &

    Ministry of Environmental;

    Key Laboratory of Environment and Health Ministry of Education &

    Ministry of Environmental;

    Key Laboratory of Environment and Health Ministry of Education &

    Ministry of Environmental;

    Key Laboratory of Environment and Health Ministry of Education &

    Ministry of Environmental;

    Jingzhou Center for Disease Control and Prevention;

    Jingzhou Center for Disease Control and Prevention;

    Jingzhou Center for Disease Control and Prevention;

    Jingzhou Center for Disease Control and Prevention;

    Key Laboratory of Environment and Health Ministry of Education &

    Ministry of Environmental;

    Key Laboratory of Environment and Health Ministry of Education &

    Ministry of Environmental;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 普通生物学;
  • 关键词

    Virus-imprinted polymer; Dopamine; Anti-viral infection; Biocompatibility; Toxicity;

    机译：病毒印迹聚合物;多巴胺;抗病毒感染;生物相容性;毒性;

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