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首页> 外文期刊>Cytokine >The high expression of the pain-related inflammatory factors in the eyes of cataract patients infected with hepatitis B virus
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The high expression of the pain-related inflammatory factors in the eyes of cataract patients infected with hepatitis B virus

机译：用乙型肝炎病毒感染的白内障患者眼中疼痛相关炎症因素的高表达

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摘要

In cataract surgery, it is often found that patients infected hepatitis B virus (HBV) are likely to suffer from more pain than other patients. In order to assess the inflammation status of the aqueous humor in the eyes of cataract patients infected with HBV. RayBio Human Inflammation Array was used to assay aqueous humor samples collected from 14 eyes of patients infected with HBV and 14 eyes of cataract patients without HBV infection (the controls) during the cataract surgery. RayBio Human Quantibody Cutom Array was adopted for the validation of the screened cytokines, with aqueous humor samples collected from 40 eyes of patients infected with HBV and 40 eyes of the controls. A pain questionnaire survey about the surgery was conducted in all patients after operation. The results of questionnaire showed that patients infected with HBV were more likely to have pain during operation. The Human Inflammation Array revealed that the expression levels of monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor alpha (TNF-alpha) and tumor necrosis factor beta (TNF-beta) were very high in HBV infected patients and IL-1ra was much lower in patients infected with HBV (all, P < 0.05). In validation, the Human Quantibody Cutom Array revealed that the expression levels of MCP-1 and TNF-alpha were high in HBV infected patients with significant difference (all P < 0.05). These results revealed that pain-related inflammatory factors MCP-1 and TNF-alpha were increased in aqueous humor of cataract patients infected with HBV, which indicates that patients infected with HBV may be more prone to intraoperative pain.
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  • 来源
    《Cytokine》 |2020年第1期|共7页
  • 作者

    Zhang Jing Shang; Wang Jin Da; Zhu Gu Yu; Yusufu Mayinuer; Xiong Ying; Li Jing; Cao Kai; Jin Shan Shan; He Hai Long; Sun Xiu Li; Wan Xiu Hua;

  • 作者单位

    Capital Med Univ Beijing Tongren Eye Ctr Beijing Inst Ophthalmol Beijing Key Lab Ophthalmol &

    Capital Med Univ Beijing Tongren Eye Ctr Beijing Inst Ophthalmol Beijing Key Lab Ophthalmol &

    Capital Med Univ Beijing Tongren Eye Ctr Beijing Inst Ophthalmol Beijing Key Lab Ophthalmol &

    Capital Med Univ Beijing Tongren Eye Ctr Beijing Inst Ophthalmol Beijing Key Lab Ophthalmol &

    Capital Med Univ Beijing Tongren Eye Ctr Beijing Key Lab Ophthalmol &

    Visual Sci Beijing Tongren;

    Capital Med Univ Beijing Tongren Eye Ctr Beijing Key Lab Ophthalmol &

    Visual Sci Beijing Tongren;

    Capital Med Univ Beijing Tongren Eye Ctr Beijing Inst Ophthalmol Beijing Key Lab Ophthalmol &

    Capital Med Univ Beijing Tongren Eye Ctr Beijing Inst Ophthalmol Beijing Key Lab Ophthalmol &

    Capital Med Univ Beijing Tongren Eye Ctr Beijing Inst Ophthalmol Beijing Key Lab Ophthalmol &

    Capital Med Univ Beijing Tongren Eye Ctr Beijing Inst Ophthalmol Beijing Key Lab Ophthalmol &

    Capital Med Univ Beijing Tongren Eye Ctr Beijing Inst Ophthalmol Beijing Key Lab Ophthalmol &

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

    Cataract; Cytokine; Inflammation; HBV; Pain;

    机译：白内障;细胞因子;炎症;HBV;疼痛;

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