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Exosomal vimentin from adipocyte progenitors accelerates wound healing

机译：来自adipocyte祖细胞的外泌体促进剂加速伤口愈合

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摘要

Adipose stem cell-derived exosomes have great potential in accelerating cutaneous wound healing by optimizing fibroblast activities. Recent studies have demonstrated that exosomes play an active role in the transport of functional cytoskeletal proteins such as vimentin. Previously we showed that vimentin serves as a coordinator of the healing process. Therefore, we hypothesized that vimentin incorporated into the exosomes may contribute to mediate fibroblast activities in wound healing. Our results revealed that exosomal vimentin from adipocyte progenitor cells acts as a promoter of fibroblast proliferation, migration, and ECM secretion. Furthermore, our in vitro and in vivo experiments provide evidence that exosomal vimentin shortens the healing time and reduces scar formation. These findings suggest the reciprocal roles of exosomes and vimentin in accelerating wound healing. Exosomes can serve as an efficient transportation system to deliver and internalize vimentin into target cells, while vimentin could have an impact on exosome transportation, internalization, and cell communication.
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  • 来源
    《Cytoskeleton》 |2020年第10期|共15页
  • 作者

    Parvanian Sepideh; Yan Fuxia; Su Dandan; Coelho-Rato Leila S.; Venu Arun P.; Yang Peiru; Zou Xiaoheng; Jiu Yaming; Chen Hongbo; Eriksson John E.; Cheng Fang;

  • 作者单位

    Sun Yat Sen Univ Sch Pharmaceut Sci Shenzhen Shenzhen Peoples R China;

    Sun Yat Sen Univ Sch Pharmaceut Sci Shenzhen Shenzhen Peoples R China;

    Sun Yat Sen Univ Sch Pharmaceut Sci Shenzhen Shenzhen Peoples R China;

    Abo Akad Univ Fac Sci &

    Engn Turku 20520 Finland;

    Abo Akad Univ Fac Sci &

    Engn Turku 20520 Finland;

    Abo Akad Univ Fac Sci &

    Engn Turku 20520 Finland;

    Sun Yat Sen Univ Sch Pharmaceut Sci Shenzhen Shenzhen Peoples R China;

    Chinese Acad Sci Inst Pasteur Shanghai Key Lab Mol Virol &

    Immunol Shanghai Peoples R China;

    Sun Yat Sen Univ Sch Pharmaceut Sci Shenzhen Shenzhen Peoples R China;

    Abo Akad Univ Fac Sci &

    Engn Turku 20520 Finland;

    Sun Yat Sen Univ Sch Pharmaceut Sci Shenzhen Shenzhen Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
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