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首页> 外文期刊>AIDS Research and Human Retroviruses >Molecular Epidemiology of HIV-1 in Jiangsu Province, Southeast China: Genotypes and HIV-1 Transmission Networks Among Newly Diagnosed Men Having Sex with Men in 2017
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Molecular Epidemiology of HIV-1 in Jiangsu Province, Southeast China: Genotypes and HIV-1 Transmission Networks Among Newly Diagnosed Men Having Sex with Men in 2017

机译：江苏省HIV-1的分子流行病学，中国东南部：新诊断的男子与男性与男性发生性关系的基因型和HIV-1传输网络

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摘要

Investigation of disease and intervention in populations of men having sex with men (MSM) has garnered attention globally, a primary reason being the rapid increase in the prevalence of human immunodeficiency virus (HIV)-1 among MSM. The purpose of this study was to understand the current HIV-1 molecular characteristics and characterize HIV-1 transmission networks in the MSM population. Nine hundred and fourteen newly diagnosed HIV-positive MSM were included in this study. The HIV-1polgene region was amplified and sequenced. A maximum likelihood phylogenetic tree was constructed, and transmission clusters were identified using 1.5% distance and 0.9 bootstrap values. In total, 767 sequences were successfully obtained, with CRF01_AE being the major genotype (43.3%, 332/767), followed by CRF07_BC (31.3%, 240/767), CRF67_01B (7.2%, 55/767), and URF (6.4%, 49/767). The transmitted HIV drug resistance rate was 4.0% (31/767), and the most common mutations were E138G (n = 4) and G190A (n = 4). A total of 182 (23.7%) sequences were included in the HIV-1 transmission networks, forming 79 clusters. Four clusters were identified as fast-growing, and the proportion of young MSM was higher than that of non-MSM (51.6% vs. 31.8%). The genetic diversity of HIV-1 in Jiangsu was complex, and cross-region transmission might exist for CRF67_01B. Transmission among young MSM within networks was greater than the other age groups; thus, they could be essential in the control of the HIV epidemic in Jiangsu. This study was approved by the ethical review board of the National Center for AIDS/STD Control and Prevention (Project No. X140617334).
机译：None

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  • 作者

    Yin Yueqi; Zhou Ying; Lu Jing; Liu Xiaoyan; Shi Lingen; Fu Gengfeng; Huan Xiping; Fang Shenghao; Liu Yuxiang; Wang Bei; Ding Jianping;

  • 作者单位

    Southeast Univ Dept Epidemiol &

    Hlth Stat Key Lab Environm Med Engn Minist Educ Sch Publ Hlth;

    Jiangsu Prov Ctr Dis Control &

    Prevent Dept HIV STD Prevent &

    Control Jiangsu Rd 172 Nanjing;

    Jiangsu Prov Ctr Dis Control &

    Prevent Dept HIV STD Prevent &

    Control Jiangsu Rd 172 Nanjing;

    Jiangsu Prov Ctr Dis Control &

    Prevent Dept HIV STD Prevent &

    Control Jiangsu Rd 172 Nanjing;

    Jiangsu Prov Ctr Dis Control &

    Prevent Dept HIV STD Prevent &

    Control Jiangsu Rd 172 Nanjing;

    Jiangsu Prov Ctr Dis Control &

    Prevent Dept HIV STD Prevent &

    Control Jiangsu Rd 172 Nanjing;

    Jiangsu Prov Ctr Dis Control &

    Prevent Dept HIV STD Prevent &

    Control Jiangsu Rd 172 Nanjing;

    Mt Sinai Hlth Syst New York NY USA;

    Southeast Univ Dept Epidemiol &

    Hlth Stat Key Lab Environm Med Engn Minist Educ Sch Publ Hlth;

    Southeast Univ Dept Epidemiol &

    Hlth Stat Key Lab Environm Med Engn Minist Educ Sch Publ Hlth;

    Jiangsu Prov Ctr Dis Control &

    Prevent Dept HIV STD Prevent &

    Control Jiangsu Rd 172 Nanjing;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 传染病;
  • 关键词

    MSM; HIV-1 transmission network; molecular epidemiology; transmitted drug resistance;

    机译：MSM;HIV-1传输网络;分子流行病学;透射耐药性;

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