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首页> 外文期刊>AIDS Research and Human Retroviruses >Molecular Genotyping of HIV-1 Strains from Newly Infected Men Who Have Sex with Men in Harbin, China
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Molecular Genotyping of HIV-1 Strains from Newly Infected Men Who Have Sex with Men in Harbin, China

机译：哈尔滨市新感染男同性恋者HIV-1毒株的分子基因分型

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In this study, blood samples from newly HIV-1 infected men who have sex with men (MSM) were collected, and HIV-1 genotypes were identified based on gag p17-p24 and nef gene regions. We found that participants aged from 20 to 40 years old were the major infection group in Harbin. CRF01_AE was the predominant genotype, contributing to 84.7% of HIV-1 infections, followed by subtype B (4.7%), CRF07_BC (3.5%), and subtype B (Thai B, 1.2%). Moreover, five unique recombinant forms (5.9%) were also identified, including genotypes 01B, 01C, and 01/02. The recombinant CRF01_AE/CRF02_AG was first reported in China. These results suggested that current HIV-1 genotype epidemic among MSM in Harbin is more complicated and that intersubtype recombinants have emerged. Therefore, timely regional epidemiological surveillance of HIV-1 genotype and development of prevention measures for new HIV-1 infections among MSM are quite important.
机译：在这项研究中，从刚与男性发生性关系（MSM）的HIV-1感染男性中采集血液样本，并根据gag p17-p24和nef基因区域鉴定出HIV-1基因型。我们发现年龄在20至40岁之间的参与者是哈尔滨的主要感染人群。 CRF01_AE是主要的基因型，占HIV-1感染的84.7％，其次是B型（4.7％），CRF07_BC（3.5％）和B型（泰国B，1.2％）。此外，还鉴定出五种独特的重组形式（5.9％），包括基因型01B，01C和01/02。重组CRF01_AE / CRF02_AG首次在中国报道。这些结果表明，目前哈尔滨MSM中HIV-1基因型的流行更为复杂，并且已经出现了亚型间的重组体。因此，对男男性接触者中的HIV-1基因型进行及时的区域流行病学监测和制定新的HIV-1感染预防措施非常重要。

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