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首页> 外文期刊>AIDS Research and Human Retroviruses >Subtype B was the dominant strain among HIV type 1 infections except for the population of men who have sex with men in harbin city, China
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Subtype B was the dominant strain among HIV type 1 infections except for the population of men who have sex with men in harbin city, China

机译：除了在中国哈尔滨市与男性发生性关系的男性人群以外，B亚型是1型HIV感染中的主要毒株。

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摘要

We sought to identify the prevalent subtypes and study the genetic variation of HIV-1 circulating in HIV infections in Harbin City, China. Forty-seven samples from the env V3-V4 region were successfully sequenced and analyzed, which involved thirty-one men who have sex with men (MSM), eight heterosexuals, seven former plasma donors (FPD)/blood transfusion recipients (BT), and one injection drug user (IDU). In all, 46.8% of CRF01-AE, 40.4% of subtype B, and 12.8% of CRF07-BC were identified. CRF01-AE (64.5%) was the dominant strain in MSM, and subtype B (81.2%) was the chief strain in other infected subjects except for the MSM population. Among all the genotypes, the B subtype possesses greater diversity of the tetramer on the tip of V3 loop than CRF07-BC and CRF01-AE, in which the peculiar GWGR was commonly found. Because nationwide there is a trend toward the increasing presence of CRF01-AE, a consecutive surveillance campaign was necessary among all HIV vulnerable populations in this locality.
机译：我们试图鉴定流行的亚型，并研究中国哈尔滨市HIV感染者中传播的HIV-1的遗传变异。成功地对来自env V3-V4区域的47个样本进行了测序和分析，其中包括31名与男性发生性关系的男性（MSM），8名异性恋者，7名前血浆供体（FPD）/输血受者（BT），一名注射吸毒者（IDU）。总共鉴定出46.8％的CRF01-AE，40.4％的B型和12.8％的CRF07-BC。 CRF01-AE（64.5％）是MSM的主要菌株，而B型（81.2％）是MSM人群以外的其他感染对象的主要菌株。在所有基因型中，B亚型在V3环末端具有比CRF07-BC和CRF01-AE大的四聚体多样性，在CRF07-BC和CRF01-AE中通常发现特有的GWGR。由于在全国范围内，CRF01-AE的存在呈增加趋势，因此有必要在该地区的所有HIV易感人群中进行连续的监视运动。

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