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首页> 外文期刊>Analytica chimica acta >Development of a screening method for analytical control of antibiotic residues by micellar electrokinetic capillary chromatography
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Development of a screening method for analytical control of antibiotic residues by micellar electrokinetic capillary chromatography

机译：胶束电动毛细管色谱法分析控制抗生素残留的筛选方法的建立

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Capillary electrophoresis was used for the separation of penicillin compounds.Micellar electrokinetic capillary chromatography (MEKC),by the addition of sodium dodecyl sulphate (SDS) to the buffer solution,demonstrated to be the appropriate mode for the separation of these compounds and their monitoring in drug residues.The method allowed to separate a mixture of antibiotics,such as amoxicillin,ampicillin,penicillin G,oxacillin,penicillin V,and cloxacillin.A mixture of 40mM sodium tetraborate and 100mM SDS at pH 8.5 was used as running buffer.The analysis was performed with a voltage of 10kV at a temperature of 20 deg C.The samples were hydrostatically introduced (10s) into the capillary and electropherograms were recorded at 210nm.Statistical analysis by Student's Mest showed no significant evidence of systematic errors in the proposed method.This method proved to be highly suitable for the separation and determination of penicillins (at mug ml~(-1) level) in farm water samples,where the presence of these compounds can produce an environmental problem.
机译：毛细管电泳用于分离青霉素化合物。胶束电动毛细管色谱法（MEKC），通过向缓冲液中添加十二烷基硫酸钠（SDS），证明是分离这些化合物和对其进行监测的合适方式。药物残留。该方法允许分离抗生素混合物，如阿莫西林，氨苄青霉素，青霉素G，奥沙西林，青霉素V和氯西林。将40mM四硼酸钠和100mM SDS的混合物（pH 8.5）用作运行缓冲液。实验是在20摄氏度的温度下以10kV的电压进行的。将样品静水压（10s）进入毛细管并在210nm处记录电泳图.Student's Mest的统计分析表明，该方法没有系统误差的明显证据。实践证明，该方法非常适用于农场水样中青霉素的分离和测定（马克杯ml〜（-1）水平）。这些化合物的存在会产生环境问题。

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